ArticleEuropean radiology2023
Intraorbital findings in giant cell arteritis on black blood MRI.
Article in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Orbital magnetic resonance imaging of giant cell arteritis with ocular manifestations: a systematic review and individual participant data meta-analysis.European radiology · 2023Pooled it
- Quantification of Vascular Burden on Cranial Vessel Wall Magnetic Resonance Imaging and Ophthalmic Complications in Giant Cell Arteritis.ACR open rheumatology · 2026Article
- Orbital MRI for diagnosing giant cell arteritis in cases of anterior ischaemic optic neuropathy.RMD open · 2026Article
- Increased optic nerve-region [Frontiers in immunology · 2026Article
- [Frontiers in immunology · 2026Article
- Ocular Manifestations of Giant Cell Arteritis.Advances in ophthalmology and optometry · 2025Article
- Vessel wall MRI in giant cell arteritis: standardized protocol and scoring approach developed by an international working group.Rheumatology (Oxford, England) · 2025Review
- Imaging Findings in Giant Cell Arteritis: Don't Turn a Blind Eye to the Obvious!AJNR. American journal of neuroradiology · 2025Review
- Enhancement within the orbits and superficial temporal artery: MRI clues to the diagnosis of giant cell arteritis.American journal of ophthalmology case reports · 2025Article
- High-resolution MRI features of nonarteritic anterior ischemic optic neuropathy: a case series.International journal of ophthalmology · 2025Article
- Optic nerve sheath measurement to monitor disease activity in giant cell arteritis: a pilot study.Clinical rheumatology · 2024Article
- Combined Orbital and Cranial Vessel Wall Magnetic Resonance Imaging for the Assessment of Disease Activity in Giant Cell Arteritis.ACR open rheumatology · 2024Article
- Clinical, laboratory, and orbital imaging features of giant cell arteritis in comparison to non-arteritic anterior ischemic optic neuropath: a single center case series.Frontiers in ophthalmology · 2024Article
- What is new in imaging to assist in the diagnosis of giant cell arteritis and Takayasu's arteritis since the EULAR and ACR/VF recommendations?Frontiers in medicine · 2024Review
- Article
- Giant Cell Arteritis: State of the Art in Diagnosis, Monitoring, and Treatment.Rambam Maimonides medical journal · 2023Review
- Interdisciplinary approach in the management of visual loss in giant cell arteritis.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
- Case Report: A rare case of ocular giant cell arteritis with bilateral orbital inflammation and diagnostic challenges.Frontiers in neurologyArticle
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Authors and funding
11 authors.
Funding
Abstract
objectiveBlindness is a feared complication of giant cell arteritis (GCA). However, the spectrum of pathologic orbital imaging findings on magnetic resonance imaging (MRI) in GCA is not well understood. In this study, we assess inflammatory changes of intraorbital structures on black blood MRI (BB-MRI) in patients with GCA compared to age-matched controls.
methodsIn this multicenter case-control study, 106 subjects underwent BB-MRI. Fifty-six patients with clinically or histologically diagnosed GCA and 50 age-matched controls without clinical or laboratory evidence of vasculitis were included. All individuals were imaged on a 3-T MR scanner with a post-contrast compressed-sensing (CS) T1-weighted sampling perfection with application-optimized contrasts using different flip angle evolution (SPACE) BB-MRI sequence. Imaging results were correlated with available clinical symptoms.
resultsEighteen of 56 GCA patients (32%) showed inflammatory changes of at least one of the intraorbital structures. The most common finding was enhancement of at least one of the optic nerve sheaths (N = 13, 72%). Vessel wall enhancement of the ophthalmic artery was unilateral in 8 and bilateral in 3 patients. Enhancement of the optic nerve was observed in one patient. There was no significant correlation between imaging features of inflammation and clinically reported orbital symptoms (p = 0.10). None of the age-matched control patients showed any inflammatory changes of intraorbital structures.
conclusionsBB-MRI revealed inflammatory findings in the orbits in up to 32% of patients with GCA. Optic nerve sheath enhancement was the most common intraorbital inflammatory change on BB-MRI. MRI findings were independent of clinically reported orbital symptoms. KEY POINTS: • Up to 32% of GCA patients shows signs of inflammation of intraorbital structures on BB-MRI. • Enhancement of the optic nerve sheath is the most common intraorbital finding in GCA patients on BB-MRI. • Features of inflammation of intraorbital structures are independent of clinically reported symptoms.
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