Evidence map›Paper›PMID 36394589›Full record

ReviewDermatologie (Heidelberg, Germany)2022

[Melanoma microenvironment-impact of modern therapies].

Judith Sirokay, Cornelia Mauch

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Dermatologie (Heidelberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Judith SirokayKlinik und Poliklinik für Dermatologie und Allergologie, Universitätsklinikum Bonn, Gebäude 11, Venusberg-Campus 1, 53127, Bonn, Deutschland. judith.sirokay@ukbonn.de.
Cornelia MauchKlinik für Dermatologie und Venerologie, Universitätsklinikum Köln, Köln, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA considerable proportion of patients with advanced melanoma succumb to metastatic disease despite the initial success of modern therapies.

objectivesAn overview of the melanoma tumor microenvironment with special focus on approved therapies and new innovative strategies is given.

methodsCurrent clinical trials and scientific insights concerning the impact of the tumor microenvironment on progression and therapy of advanced melanoma are reviewed and discussed.

resultsThe tumor microenvironment with its manifold components and interactions plays a major role in the treatment of malignant melanoma.

conclusionInnovative new strategies that target an immunosuppressive microenvironment may improve the therapeutic efficacy of current treatment of advanced melanoma.

Indexed as

MelanomaNeoplasms, Second PrimarySkin NeoplasmsHumansImmunosuppressive AgentsTumor MicroenvironmentImmunosuppressive AgentsImmunotherapyNew therapeutic strategiesSystemic therapiesTargeted therapyTherapeutic response

Identifiers

PMID36394589

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.