Evidence map›Paper›PMID 36394322›Full record

ArticleApplied and environmental microbiology2022

Evidence for Widespread Class II Microcins in

T Jeffrey Cole, Jennifer K Parker, Aaron L Feller, Claus O Wilke, Bryan W Davies

Open access · hybridAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Prevalence and activity of class II microcins inApplied and environmental microbiology · 2026
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  11. Review
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  13. Article
  14. Microbiology (Reading, England) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

T Jeffrey Cole *Department of Integrative Biology, The University of Texas at Austin, Austin, Texas, USA.
Jennifer K Parker *Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA.ORCID 0000-0002-4382-0741
Aaron L FellerDepartment of Integrative Biology, The University of Texas at Austin, Austin, Texas, USA.ORCID 0000-0002-4476-1026
Claus O WilkeDepartment of Integrative Biology, The University of Texas at Austin, Austin, Texas, USA.ORCID 0000-0002-7470-9261
Bryan W DaviesDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA.ORCID 0000-0002-2046-0341
The University of Texas at Austin · US

Funding

Investigating nanobodies to target multidrug resistant bacterial pathogensR01AI148419 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI DAVIES, BRYAN WILLIAM · 2020 to 2023
$2.8M
A High-Throughput Molecular Platform for Antimicrobial Discovery and StudyR01AI125337 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI DAVIES, BRYAN WILLIAM · 2016 to 2020
$2.0M
Investigation of capsule interactions that promote antimicrobial peptide activityR21AI159203 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI DAVIES, BRYAN WILLIAM · 2021 to 2022
$429k
NIAID NIH HHS R01 AI125337NIAID NIH HHS R01 AI148419NIAID NIH HHS R21 AI159203
6 · The paper itself

Abstract

Microcins are a class of antimicrobial peptides produced by certain Gram-negative bacterial species to kill or inhibit the growth of competing bacteria. Only 10 unique, experimentally validated class II microcins have been identified, and the majority of these come from Escherichia coli. Although the current representation of microcins is sparse, they exhibit a diverse array of molecular functionalities, uptake mechanisms, and target specificities. This broad diversity from such a small representation suggests that microcins may have untapped potential for bioprospecting peptide antibiotics from genomic data sets. We used a systematic bioinformatics approach to search for verified and novel class II microcins in E. coli and other species within its family,

Indexed as

BacteriocinsEscherichia coliAnti-Bacterial AgentsBacteriaEnterobacteriaceaePeptidesPhylogenyAnti-Bacterial AgentsBacteriocinsmicrocinPeptidesbacteriocinsbioinformaticscomputational biologyEnterobacteriaceaeGram-negative bacteriamicrocin

Identifiers

PMID36394322
PMCPMC9746304
OpenAlexW4309245599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.