Evidence map›Paper›PMID 36394163›Full record

ArticleAnnals of clinical and translational neurology2022

Harmonizing results of ataxia rating scales: mFARS, SARA, and ICARS.

Christian Rummey, Ian H Harding, Martin B Delatycki, Geneieve Tai, Thiago Rezende, Louise A Corben

Abstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. The Pattern and Stages of Atrophy in Spinocerebellar Ataxia Type 2: Volumetrics from ENIGMA-Ataxia.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  3. The Therapeutic Future for Congenital Disorders of Glycosylation.Journal of inherited metabolic disease · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Retinal hypoplasia and degeneration result in vision loss in Friedreich ataxia.Annals of clinical and translational neurology · 2023
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christian RummeyClinical Data Science GmbH, Basel, Switzerland.ORCID https://orcid.org/0000-0003-4911-911X
Ian H HardingDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-6843-9592
Martin B DelatyckiBruce Lefroy Centre for Genetic Health Research, Murdoch Children's Research Institute, Parkville, 3052, Victoria, Australia.
Geneieve TaiBruce Lefroy Centre for Genetic Health Research, Murdoch Children's Research Institute, Parkville, 3052, Victoria, Australia.
Thiago RezendeDepartment of Neurology, University of Campinas, Campinas, Brazil.ORCID https://orcid.org/0000-0001-8453-0313
Louise A CorbenBruce Lefroy Centre for Genetic Health Research, Murdoch Children's Research Institute, Parkville, 3052, Victoria, Australia.

Funding

Friedreich's Ataxia Research Alliance
6 · The paper itself

Abstract

The ever-increasing body of ataxia research provides opportunities for large-scale meta-analyses, systematic reviews, and data aggregation. Because multiple standardized scales are used to quantify ataxia severity, harmonization of these measures is necessary for quantitative data pooling. We applied the modified Friedreich Ataxia Rating Scale (mFARS), the Scale for the Assessment and Rating of Ataxia (SARA), and the International Cooperative Ataxia Rating Scale (ICARS) to a large cohort of people with Friedreich's ataxia. We provide regression coefficients for scale interconversion and discuss the reliability of this approach, together with insights into the differential sensitivities of mFARS and SARA to disease progression.

Indexed as

Cerebellar AtaxiaFriedreich AtaxiaAtaxiaHumansReproducibility of ResultsSeverity of Illness Index

Identifiers

PMID36394163
PMCPMC9735370

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.