Evidence map›Paper›PMID 36394162›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Non-Invasive 3D Photoacoustic Tomography of Angiographic Anatomy and Hemodynamics of Fatty Livers in Rats.

Xin Tong, Li Lin, Peng Hu, Rui Cao, Yang Zhang, Joshua Olick-Gibson, Lihong V Wang

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Xin TongCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Li LinCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Peng HuCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Rui CaoCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Yang ZhangCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Joshua Olick-GibsonCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Lihong V WangCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.ORCID 0000-0001-9783-4383
California Institute of Technology · US

Funding

High-speed panoramic 3D photoacoustic computed tomography of the breastR35CA220436 · NCI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI WANG, LIHONG · 2018 to 2024
$6.4M
NCI NIH HHS R35 CA220436NIH HHS R35 CA220436
6 · The paper itself

Abstract

Non-alcoholic fatty liver disease is the most common liver disorder worldwide, which strongly correlates to obesity, diabetes, and metabolic syndromes. Complementary to mainstream liver diagnostic modalities, photoacoustic tomography (PAT) can provide high-speed images with functional optical contrast. However, PAT has not been demonstrated to study fatty liver anatomy with clear volumetric vasculatures. The livers of multiple rats are non-invasively imaged in vivo using the recently developed 3D PAT platform. The system provides isotropically high spatial resolution in 3D space, presenting clear angiographic structures of rat livers without injecting contrast agents. Furthermore, to quantitatively analyze the difference between the livers of lean and obese rats, the authors measured several PAT features and statistical differences between the two groups are observed. In addition to the anatomy, a time-gated strategy is applied to correct respiration-induced motion artifacts and extracted the hemodynamics of major blood vessels during the breathing cycles. This study demonstrates the capabilities of 3D-PAT to reveal both angiographic anatomy and function in rat livers, providing hematogenous information for fatty liver diagnosis. 3D-PAT, as a new tool for preclinical research, warrants further improvements to be transferred to human pediatric liver imaging.

Indexed as

Fatty LiverTomography, X-Ray ComputedAnimalsChildContrast MediaHemodynamicsHumansRatsContrast Mediahepatic steatosisliver imagingnon-alcoholic fatty liverphotoacoustic computed tomography

Identifiers

PMID36394162
PMCPMC9839842
OpenAlexW4309172799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.