Evidence map›Paper›PMID 36393849›Full record

ArticleFrontiers in cell and developmental biology2022

Age-dependent increase of cytoskeletal components in sensory axons in human skin.

Klara Metzner, Omar Darawsha, Mengzhe Wang, Nayana Gaur, Yiming Cheng, Annekathrin Rödiger, Christiane Frahm, Otto W Witte, Fabiana Perocchi, Hubertus Axer and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Alterations of actin in aging.Journal of cell science · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Ageing in the brain: mechanisms and rejuvenating strategies.Cellular and molecular life sciences : CMLS · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Klara MetznerDepartment of Neurology, Jena University Hospital, Jena, Germany.
Omar DarawshaInstitute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.
Mengzhe WangInstitute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.
Nayana GaurDepartment of Neurology, Jena University Hospital, Jena, Germany.
Yiming ChengHelmholtz Diabetes Center (HDC), Helmholtz Center Munich, Institute for Diabetes and Obesity, Munich, Germany.
Annekathrin RödigerDepartment of Neurology, Jena University Hospital, Jena, Germany.
Christiane FrahmDepartment of Neurology, Jena University Hospital, Jena, Germany.
Otto W WitteDepartment of Neurology, Jena University Hospital, Jena, Germany.
Fabiana PerocchiInstitute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.
Hubertus AxerDepartment of Neurology, Jena University Hospital, Jena, Germany.
Julian GrosskreutzPrecision Neurology of the University of Lübeck, Lübeck, Germany.
Monika S BrillInstitute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.
Jena University Hospital · DEHelmholtz Zentrum München · DEMunich Cluster for Systems Neurology · DEUniversity of Lübeck · DEUniversity of Tartu · EE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is a complex process characterized by several molecular and cellular imbalances. The composition and stability of the neuronal cytoskeleton is essential for the maintenance of homeostasis, especially in long neurites. Using human skin biopsies containing sensory axons from a cohort of healthy individuals, we investigate alterations in cytoskeletal content and sensory axon caliber during aging

Indexed as

actinaging adultshuman skin biopsymicrotubuleneurofilamentsensory axon

Identifiers

PMID36393849
PMCPMC9664158
OpenAlexW4307761825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.