Evidence map›Paper›PMID 36389807›Full record

ArticleFrontiers in immunology2022

Lymphocyte antigen 6 complex locus G6D downregulation is a novel parameter for functional impairment of neutrophils in aged mice.

Suguru Saito, Alato Okuno, Toshio Maekawa, Ryoki Kobayashi, Osamu Yamashita, Noriyuki Tsujimura, Morihiko Inaba, Yasushi Kageyama, Noriko M Tsuji

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Suguru SaitoDivision of Cellular and Molecular Engineering, Department of Life Technology and Science, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
Alato OkunoDivision of Cellular and Molecular Engineering, Department of Life Technology and Science, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
Toshio MaekawaDivision of Cellular and Molecular Engineering, Department of Life Technology and Science, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
Ryoki KobayashiDivision of Cellular and Molecular Engineering, Department of Life Technology and Science, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
Osamu YamashitaTechnical Service Department, CLEA Japan, Inc., Tokyo, Japan.
Noriyuki TsujimuraTechnical Service Department, CLEA Japan, Inc., Tokyo, Japan.
Morihiko InabaTokyo Animal and Diet Department, CLEA Japan, Inc., Tokyo, Japan.
Yasushi KageyamaTokyo Animal and Diet Department, CLEA Japan, Inc., Tokyo, Japan.
Noriko M TsujiDivision of Cellular and Molecular Engineering, Department of Life Technology and Science, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
Nihon University · JPJumonji University · JPNational Institute of Advanced Industrial Science and Technology · JPUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunological aging is a critical event that causes serious functional impairment in the innate immune system. However, the identification markers and parameters are still poorly understood in immunological aging of myeloid lineage cells. Here, we show that a downregulation of lymphocyte antigen 6 complex locus G6D (Ly-6G) observed in aged mouse neutrophils could serve as a novel marker for the prediction of age-associated functional impairment in the neutrophils. Ly-6G expression was significantly downregulated in the bone marrow (BM) neutrophils of aged mice compared to young mice confirmed by flow cytometry analysis

Indexed as

Extracellular TrapsNeutrophilsAnimalsDown-RegulationHistocompatibility AntigensLymphocytesMicePhagocytosisHistocompatibility Antigensaginganti-bacterial immunitylymphocyte antigen 6 complex locus G6D (Ly-6G)myeloid lineage cellsneutrophils

Identifiers

PMID36389807
PMCPMC9647080
OpenAlexW4307635211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.