Evidence map›Paper›PMID 36389671›Full record

ArticleFrontiers in immunology2022

CD4

Martina Dicker, Yingcong Li, Daniel A Giles, Greet Verstichel, Viankail Cedillo Castelan, Gabriel Ascui-Gac, Ting-Fang Chou, Tamara Perez-Jeldres, Hilde Cheroutre, Mitchell Kronenberg

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Martina DickerCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Yingcong LiCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Daniel A GilesCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Greet VerstichelCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Viankail Cedillo CastelanCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Gabriel Ascui-GacCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Ting-Fang ChouCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Tamara Perez-JeldresCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Hilde CheroutreCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
Mitchell KronenbergCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, United States.
La Jolla Institute for Immunology · USUniversity of California, San Diego · US

Funding

Using polygenic scores to enhance both variant discovery, and understanding of functional consequences of genetic variation in IBD.P01DK046763 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI TARGAN, STEPHAN R. · 1992 to 2020
$31.1M
The role of GPR183 in Inflammatory Bowel Disease pathogenesisF32AI140581 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI GILES, DANIEL AARON · 2018 to 2019
$89k
NIAID NIH HHS F32 AI140581NIDDK NIH HHS P01 DK046763
6 · The paper itself

Abstract

Colitis is characterized by an exacerbated intestinal immune response, but the genetic and other mechanisms regulating immune activation remain incompletely understood. In order to identify new pathways leading to colitis, we sought to identify genes with increased expression in the colons of patients that also are near loci identified by genome wide association studies (GWAS) associated with IBD risk. One such SNP, rs9557195 was of particular interest because it is within an intron of

Indexed as

ColitisGenome-Wide Association StudyAnimalsCD4-Positive T-LymphocytesDextran SulfateDisease Models, AnimalHumansMiceMice, Inbred C57BLReceptors, G-Protein-CoupledDextran SulfateGPR183 protein, humanGpr183 protein, mouseGPR18 protein, humanGPR18 protein, mouseReceptors, G-Protein-Coupledchemokine receptorDSS modelgene expressioninflammatory bowel diseaseT cell transfer model

Identifiers

PMID36389671
PMCPMC9652117
OpenAlexW4307464940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.