Evidence map›Paper›PMID 36389417›Full record

ArticlePeerJ2022

Age, adrenal steroids, and cognitive functioning in captive chimpanzees (

Rafaela S C Takeshita, Melissa K Edler, Richard S Meindl, Chet C Sherwood, William D Hopkins, Mary Ann Raghanti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Rafaela S C TakeshitaDepartment of Anthropology, Kent State University, Kent, OH, USA.
Melissa K EdlerDepartment of Anthropology, Kent State University, Kent, OH, USA.
Richard S MeindlDepartment of Anthropology, Kent State University, Kent, OH, USA.
Chet C SherwoodDepartment of Anthropology, The George Washington University, Washington, DC, USA.
William D HopkinsDepartment of Comparative Medicine, The University of Texas MD Anderson Cancer Center, Bastrop, TX, USA.
Mary Ann RaghantiDepartment of Anthropology, Kent State University, Kent, OH, USA.
Kent State University · USGeorge Washington University · USThe University of Texas MD Anderson Cancer Center · US

Funding

Alzheimer's Disease Pathology in a Primate ModelR01AG067419 · NIA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HOPKINS, WILLIAM D · 2021 to 2025
$3.8M
NIA NIH HHS R01 AG067419
6 · The paper itself

Abstract

Background: Dehydroepiandrosterone-sulfate is the most abundant circulating androgen in humans and other catarrhines. It is involved in several biological functions, such as testosterone production, glucocorticoid antagonist actions, neurogenesis and neuroplasticty. Although the role of dehydroepiandrosterone-sulfate (DHEAS) in cognition remains elusive, the DHEAS/cortisol ratio has been positively associated with a slower cognitive age-decline and improved mood in humans. Whether this relationship is found in nonhuman primates remains unknown. Methods: We measured DHEAS and cortisol levels in serum of 107 adult chimpanzees to investigate the relationship between DHEAS levels and age. A subset of 21 chimpanzees was used to test the potential associations between DHEAS, cortisol, and DHEAS/cortisol ratio in cognitive function, taking into account age, sex, and their interactions. We tested for cognitive function using the primate cognitive test battery (PCTB) and principal component analyses to categorize cognition into three components: Results: DHEAS levels, but not the DHEAS/cortisol ratio, declined with age in chimpanzees. Our analyses for

Indexed as

HydrocortisonePan troglodytesAdultAnimalsCognitionDehydroepiandrosterone SulfateHumansSteroidsSulfatesDehydroepiandrosterone SulfateHydrocortisoneSteroidsSulfatesAgingChimpanzeeCognitionCortisolDehydroepiandrosterone-sulfateSteroid hormones

Identifiers

PMID36389417
PMCPMC9653054
OpenAlexW4308603589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.