Evidence map›Paper›PMID 36389000›Full record

ArticleiScience2022

Citrate shuttling in astrocytes is required for processing cocaine-induced neuron-derived excess peroxidated fatty acids.

Kalimuthusamy Natarajaseenivasan, Alvaro Garcia, Prema Velusamy, Santhanam Shanmughapriya, Dianne Langford

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Kalimuthusamy NatarajaseenivasanDepartment of Neural Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Alvaro GarciaDepartment of Neural Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Prema VelusamyHeart and Vascular Institute, Department of Medicine, Department of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine, Hershey, PA, USA.
Santhanam ShanmughapriyaHeart and Vascular Institute, Department of Medicine, Department of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine, Hershey, PA, USA.
Dianne LangfordDepartment of Neural Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Pennsylvania State University · USTemple University · USBharathidasan University · IN

Funding

Viral Gene Editing and Bioinformatics Core for Institution # 269291P30MH092177 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI Kamel Khalili · 2011 to 2026
$24.9M
Project 3 Dysregulation of metabolic communication of oligodendrocytes and neurons by cocaine and TatP01DA037830 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI KHALILI, KAMEL · 2015 to 2019
$7.4M
Interdisciplinary And Translational Research Training In NeurohivT32MH079785 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI Kamel Khalili · 2008 to 2026
$5.4M
HIV and Cocaine Use Leads to Loss of Astrocyte Neurotrophic Support and Impaired Lipid Homeostasis in the BrainR01NS124478 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI Dianne Teresa LANGFORD · 2022 to 2026
$2.5M
PINCH-mediated CNS cell dysfunction and tauopathy in HIVR01MH107340 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI LANGFORD, DIANNE TERESA · 2016 to 2020
$2.0M
Molecular link between MCU and Mrs2p channels for mitochondrial ion homeostasis and energy metabolismR00HL138268 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SANTHANAM, SHANMUGHAPRIYA · 2019 to 2021
$747k
HIV and cocaine use leads to loss of astrocyte neurotrophic support and impaired lipid homeostasis in the brainR56NS124478 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI LANGFORD, DIANNE TERESA · 2021 to 2021
$521k
Cocaine upregulates mitochondria-derived vesicular pathway for selective removal of oxidized cargoR21DA051798 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI KALIMUTHUSAMY, NATARAJASEENIVASAN · 2020 to 2021
$436k
NHLBI NIH HHS R00 HL138268NIDA NIH HHS P01 DA037830NIDA NIH HHS R21 DA051798NIMH NIH HHS P30 MH092177NIMH NIH HHS R01 MH107340NIMH NIH HHS T32 MH079785NINDS NIH HHS R01 NS124478NINDS NIH HHS R56 NS124478
6 · The paper itself

Abstract

Disturbances in lipid metabolism in the CNS contribute to neurodegeneration and cognitive impairments. Through tight metabolic coupling, astrocytes provide energy to neurons by delivering lactate and cholesterol and by taking up and processing neuron-derived peroxidated fatty acids (pFA). Disruption of CNS lipid homeostasis is observed in people who use cocaine and in several neurodegenerative disorders, including HIV. The brain's main source of energy is aerobic glycolysis, but numerous studies report a switch to β-oxidation of FAs in response to cocaine. Unlike astrocytes, in response to cocaine, neurons cannot efficiently consume excess pFAs for energy. Accumulation of pFA in neurons induces autophagy and release of pFA. Astrocytes endocytose the pFA for oxidation as an energy source. Our data show that blocking mitochondrial/cytosolic citrate transport reduces the neurotrophic capacity of astrocytes, leading to decreased neuronal fitness.

Indexed as

Cell biologyCellular neuroscienceNeuroscience

Identifiers

PMID36389000
PMCPMC9646946
OpenAlexW4306894005

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.