Evidence map›Paper›PMID 36388989›Full record

ArticleiScience2022

Combinatorial prophylactic effect of phlorotannins with photobiomodulation against tracheal stenosis.

Yeachan Lee, Seong-Yeong Heo, Hyoung Shin Lee, Sun-Ju Oh, Hyeonsoo Kim, Seonghee Lim, Hwarang Shin, Won-Kyo Jung, Hyun Wook Kang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yeachan LeeIndustry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Korea.
Seong-Yeong HeoJeju Marine Research Center, Korea Institute of Ocean Science & Technology (KIOST), Jeju 63349, Korea.
Hyoung Shin LeeDepartment of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan 49267, Korea.
Sun-Ju OhDepartment of Pathology, Kosin University College of Medicine, Busan 49267, Korea.
Hyeonsoo KimIndustry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Korea.
Seonghee LimIndustry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Korea.
Hwarang ShinIndustry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Korea.
Won-Kyo JungIndustry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Korea.
Hyun Wook KangIndustry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Korea.
Pukyong National University · KRKosin University · KRKorea Institute of Ocean Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several conventional treatments are used to manage tracheal stenosis after intubation and surgical procedures; however, patients are at risk of restenosis because of the absence of effective preventative therapy. In this study, we evaluate the biomodulatory effect of PT-combined blue light (BL) PBM in tracheostomal stenosis-induced animal models. The PT-combined BL group showed a significant decrease in the fibrotic protein synthesis by downregulating the release of stenosis-triggering fibrotic signals, without cytotoxicity or thermal damage. Moreover, the combined treatment ameliorated excessive granulation and collagen formation, and consequently preserved the opening of the tracheostoma ten days after fenestration. The current study demonstrated the biomodulatory effect of PT-combined BL on human tracheal fibroblasts and tracheal fenestration rodent models. Hence, PT-combined BL has the potential to be an effective preventative treatment for tracheal stenosis but also as an alternative option for fibrotic disorders.

Indexed as

Combination therapyPhlorotanninsPhotobiomodulationPreventive medicineTracheal stenosis

Identifiers

PMID36388989
PMCPMC9664362
OpenAlexW4306777881

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.