Evidence map›Paper›PMID 36388965›Full record

ArticleiScience2022

Cell-intrinsic differences between human airway epithelial cells from children and adults.

Elizabeth F Maughan, Robert E Hynds, Adam Pennycuick, Ersilia Nigro, Kate H C Gowers, Celine Denais, Sandra Gómez-López, Kyren A Lazarus, Jessica C Orr, David R Pearce and 16 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

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  15. Open questions in human lung organoid research.Frontiers in pharmacology · 2022
    Review
  16. Review
  17. Article
  18. COVID-19 in Immunosuppressed Children.Frontiers in pediatrics · 2021
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 4 institutions in 1 country.

Elizabeth F MaughanLungs for Living Research Centre, UCL Respiratory, University College London, London WC1E 6JF, UK.
Robert E HyndsEpithelial Cell Biology in ENT Research (EpiCENTR) Group, Developmental Biology and Cancer Department, UCL Great Ormond Street Institute of Child Health, University College London, London WC1N 1DZ, UK.
Adam PennycuickLungs for Living Research Centre, UCL Respiratory, University College London, London WC1E 6JF, UK.
Ersilia NigroLungs for Living Research Centre, UCL Respiratory, University College London, London WC1E 6JF, UK.
Kate H C GowersLungs for Living Research Centre, UCL Respiratory, University College London, London WC1E 6JF, UK.
Celine DenaisLungs for Living Research Centre, UCL Respiratory, University College London, London WC1E 6JF, UK.
Sandra Gómez-LópezLungs for Living Research Centre, UCL Respiratory, University College London, London WC1E 6JF, UK.
Kyren A LazarusLungs for Living Research Centre, UCL Respiratory, University College London, London WC1E 6JF, UK.
Jessica C OrrLungs for Living Research Centre, UCL Respiratory, University College London, London WC1E 6JF, UK.
David R PearceUniversity College London Cancer Institute, University College London, London WC1E 6DD, UK.
Sarah E ClarkeLungs for Living Research Centre, UCL Respiratory, University College London, London WC1E 6JF, UK.
Dani Do Hyang LeeInfection, Immunity and Inflammation Department, UCL Great Ormond Street Institute of Child Health, University College London, London WC1E 1EH, UK.
Maximillian N J WoodallInfection, Immunity and Inflammation Department, UCL Great Ormond Street Institute of Child Health, University College London, London WC1E 1EH, UK.
Tereza MasonouInfection, Immunity and Inflammation Department, UCL Great Ormond Street Institute of Child Health, University College London, London WC1E 1EH, UK.
Katie-Marie CaseInfection, Immunity and Inflammation Department, UCL Great Ormond Street Institute of Child Health, University College London, London WC1E 1EH, UK.
Vitor H TeixeiraLungs for Living Research Centre, UCL Respiratory, University College London, London WC1E 6JF, UK.
Benjamin E HartleyTracheal Service, Great Ormond Street Hospital, London WC1N 3JH, UK.
Richard J HewittTracheal Service, Great Ormond Street Hospital, London WC1N 3JH, UK.
Chadwan Al YaghchiThe National Centre for Airway Reconstruction, Department of Otolaryngology, Charing Cross Hospital, London W6 8RF, UK.
Gurpreet S SandhuThe National Centre for Airway Reconstruction, Department of Otolaryngology, Charing Cross Hospital, London W6 8RF, UK.
Martin A BirchallUniversity College London Ear Institute, University College London, London WC1X 8EE, UK.
Christopher O'CallaghanInfection, Immunity and Inflammation Department, UCL Great Ormond Street Institute of Child Health, University College London, London WC1E 1EH, UK.
Claire M SmithInfection, Immunity and Inflammation Department, UCL Great Ormond Street Institute of Child Health, University College London, London WC1E 1EH, UK.
Paolo De CoppiStem Cell and Regenerative Medicine Section, University College London Great Ormond Street Institute of Child Health, University College London, London WC1N 1DZ, UK.
Colin R ButlerEpithelial Cell Biology in ENT Research (EpiCENTR) Group, Developmental Biology and Cancer Department, UCL Great Ormond Street Institute of Child Health, University College London, London WC1N 1DZ, UK.
Sam M JanesLungs for Living Research Centre, UCL Respiratory, University College London, London WC1E 6JF, UK.
University College London · GBGreat Ormond Street Hospital · GBCharing Cross Hospital · GBLondon Cancer · GB

Funding

Molecular Atlas of Lung Development - Data Coordinating CenterU01HL122638 · NHLBI · DUKE UNIVERSITY · PI CLARK, ROBERT F, PALMER, SCOTT M · 2014 to 2018
$7.5M
"Lung MAP" Atlas Research CenterU01HL122642 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI POTTER, S. STEVEN, WHITSETT, JEFFREY A · 2014 to 2018
$3.9M
Medical Research Council G108/596Medical Research Council MR/R015635/1NHLBI NIH HHS U01 HL122638NHLBI NIH HHS U01 HL122642Wellcome Trust 209199/Z/17/Z
6 · The paper itself

Abstract

The airway epithelium is a protective barrier that is maintained by the self-renewal and differentiation of basal stem cells. Increasing age is a principle risk factor for chronic lung diseases, but few studies have explored age-related molecular or functional changes in the airway epithelium. We retrieved epithelial biopsies from histologically normal tracheobronchial sites from pediatric and adult donors and compared their cellular composition and gene expression profile (in laser capture-microdissected whole epithelium, fluorescence-activated cell-sorted basal cells, and basal cells in cell culture). Histologically, pediatric and adult tracheobronchial epithelium was similar in composition. We observed age-associated changes in RNA sequencing studies, including higher interferon-associated gene expression in pediatric epithelium. In cell culture, pediatric cells had higher colony formation ability, sustained

Indexed as

Medical scienceMolecular biologyPediatrics

Identifiers

PMID36388965
PMCPMC9664344
OpenAlexW4306893699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.