SynthesisFrontiers in medicine2022
Impact of frailty, mild cognitive impairment and cognitive frailty on adverse health outcomes among community-dwelling older adults: A systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Frailty and Health Outcomes in People 65 Years or Older Living With Dementia: A Systematic Review of the Literature.Journal of the American Geriatrics Society · 2026Pooled it
- Cognitive impairment and hospital admission risk among community-dwelling adults in the MAUCO cohort.Annals of medicine · 2026Article
- Mediators of attachment, frailty, and mild cognitive impairment in older adults.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- The association of self- and interviewer-reported cognitive problems with frailty progression and subsequent all-cause mortality risk: a large-scale cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Multidimensional Frailty and Resilience in Relation to Quality of Life in Senior Patients with Cardiovascular Disease: An Exploratory Cross-Sectional Pilot Study.Journal of clinical medicine · 2026Article
- Cognitive frailty and adverse outcomes in older people with maintenance hemodialysis: a multicenter prospective cohort study.BMC geriatrics · 2026Article
- Robustness in Older Adults: A Concept Analysis Using Rodgers' Evolutionary Approach.Nursing & health sciences · 2026Review
- Aerobic Exercise Combined with Multisensory Stimulation Training Improves Cognitive Frailty by Modulating Circulating Klotho.International journal of molecular sciences · 2026Article
- Cognitive frailty and associated factors in older adults with type 2 diabetes in rural Vietnam.BMC geriatrics · 2026Article
- Prevalence and risk factors of loneliness in older adults with preclinical and prodromal Alzheimer's disease: the impact of depression, frailty-weight loss and quality of life.BMC geriatrics · 2026Article
- Association of frailty and disability in community dwelling older adults: a cross sectional study.Scientific reports · 2026Article
- Evaluating the association of physical frailty with cognitive impairment: a clinical perspective in older adults of Bangladesh.BMC geriatrics · 2026Article
- Single-task, dual-task, and community gait speeds of older adults in Singapore: their associations with frailty, cognition, and age-friendly cities.Innovation in aging · 2026Article
- Machine learning-based prediction model for cognitive frailty in elderly patients with ischaemic stroke: a prospective cohort study.Frontiers in neurology · 2026Article
- Four-Limb Coordinated Training and Neuroplasticity in Older Adults with Cognitive Frailty: Mechanisms and Clinical Evidence.Clinical interventions in aging · 2026Review
- The association between frailty and headache in middle-aged and older individuals: a data analysis based on the GBD2021, the CHARLS and Mendelian randomization.Archives of medical science : AMS · 2026Article
- Transitions across the cognitive frailty spectrum and its association with anxiety in individuals aged 55 years and over: a 7 years longitudinal study.Scientific reports · 2025Article
- Abnormalities of resting-state EEG microstates in older adults with cognitive frailty.GeroScience · 2025Article
- Predicting cognitive frailty in community-dwelling older adults: a machine learning approach based on multidomain risk factors.Scientific reports · 2025Article
- Combined impact of neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and cognitive function on all-cause mortality in older adults: a population-based study.Lipids in health and disease · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: This study analyzes the impact of frailty, mild cognitive impairment, and cognitive frailty on adverse outcomes in community-dwelling older adults. Methods: This systematic review and meta-analysis were conducted using the PRISMA guidelines and MOOSE statement. We developed a specific search strategy for each electronic database and searched PubMed, Web of Science, MEDLINE, and Embase from initial records to July 2021. The studies on adverse outcomes of frailty, pre-frailty, mild cognitive impairment, and mild cognitive impairment with pre-frailty and cognitive frailty were included. Two researchers independently extracted data based on a spreadsheet and assessed the risk of bias. The primary outcomes were mortality, dementia, disability, and hospitalization. The second outcome included quality of life and falls. All analysis was conducted by using Review Manager (RevMan) 5.3 software. Results: A total of 22 cohort studies (71,544 older adults with mean age ranging from 65.1 to 93.6 years) were included with a low risk of bias and high methodological quality with a NOS score ≥7. Compared to robust elders, individuals identified as frailty were associated with a higher risk of mortality (RR = 2.11, 95% CI: 1.57-2.83) and disability (RR = 5.91, 95% CI: 2.37-14.74). Mild cognitive impairment with pre-frailty was associated with mortality (RR = 1.74, 95% CI: 1.48-2.05) and dementia (RR = 4.15, 95% CI: 1.87-9.20). Pre-frailty was associated with a higher risk of mortality (RR = 1.29, 95% CI: 1.11-1.50). Cognitive frailty was associated with higher risk of incident mortality (RR = 2.41, 95% CI: 1.97-2.94), dementia (RR = 3.67, 95% CI: 2.81-4.78), disability (RR = 11.32, 95% CI: 4.14-30.97), and hospitalization (RR = 2.30, 95% CI: 1.60-3.32), as well as poor quality of life. Conclusion: Cognitive frailty could be a comprehensive psychosomatic predictor for adverse outcomes among older people. Interactions between frailty, mild cognitive impairment, and cognitive frailty on adverse outcomes must be further explored. Systematic review registration: [https://inplasy.com/inplasy-2022-5-0064/], identifier [INPLASY202250064].
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