ArticleAnnals of translational medicine2022
Platelet-rich plasma promotes diabetic ulcer repair through inhibition of ferroptosis.
Article in Annals of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Trial
- Deciphering the Iron Metabolism and Ferroptosis in Diabetic Wound Healing.Current diabetes reviews · 2026Review
- Blood derivatives as monotherapy and combination therapy: A promising strategy for wound healing.Regenerative therapy · 2025Review
- Research progress on the role and mechanisms of ferroptosis in diabetic wound repair.Cell death discovery · 2025Review
- Study of the effects and mechanism of allogeneic platelet-rich plasma gel on layered skin flaps.Scientific reports · 2025Article
- A Comprehensive Literature Review on the Therapeutic Potential of Platelet-Rich Plasma for Diabetic Foot Management: Insights from a Case of a Neglected Deep Plantar Abscess.Healthcare (Basel, Switzerland) · 2025Review
- Research Hotspots in Natural Products for Wound Healing: A Bibliometric Analysis and Literature Review.Clinical, cosmetic and investigational dermatology · 2025Review
- Progress in the clinical application of allogeneic platelet-rich plasma for diabetic foot treatment.Frontiers in endocrinology · 2025Review
- Protective Effects of Hydrogen Treatment Against High Glucose-Induced Oxidative Stress and ApoptosisEndocrine, metabolic & immune disorders drug targets · 2025Article
- Mitochondrial dysfunction in diabetic ulcers: pathophysiological mechanisms and targeted therapeutic strategies.Frontiers in cell and developmental biology · 2025Review
- Platelet-rich plasma may accelerate diabetic wound healing by modulating epithelial/endothelial-mesenchymal transition through inhibiting reactive oxygen species-mediated oxidative stress.Frontiers in bioengineering and biotechnology · 2025Article
- Effect of preoperative autologous platelet-rich plasmapheresis on postoperative bleeding in patients undergoing heart valve surgery.Journal of thoracic disease · 2024Article
- Advances and Challenges in Immune-Modulatory Biomaterials for Wound Healing Applications.Pharmaceutics · 2024Review
- Advances in Ferroptosis-Inducing Agents by Targeted Delivery System in Cancer Therapy.International journal of nanomedicine · 2024Review
- Research progress on and molecular mechanism of vacuum sealing drainage in the treatment of diabetic foot ulcers.Frontiers in surgery · 2024Review
- Neutrophils extracellular traps and ferroptosis in diabetic wounds.International wound journal · 2023Review
- Article
- The Road from AKI to CKD: Molecular Mechanisms and Therapeutic Targets of Ferroptosis.Cell death & disease · 2023Review
- Deciphering The Emerging Role of Programmed Cell Death in Diabetic Wound Healing.International journal of biological sciences · 2023Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Ferroptosis, a newly discovered form of cell death, can accumulation activates lipid peroxidation and excessive oxidative stress in a high glucose environment. These phenomena suggest there may be ferroptosis pathways in the pathological processes associated with diabetic ulcer (DU). Platelet-rich plasma (PRP) promotes the healing of DU wounds, which may be achieved by the regulation of ferroptosis pathways. Hence, the present study aimed to investigate this association and uncover the potential underlying mechanisms. Methods: Cell injury models induced by high glucose were constructed using EA.HY926 (vascular endothelial cells), HSF (fibroblasts), and rat DU models. The MDA, total ROS, total SOD content, the gene and protein expression of Results: The results show that compared with the DU control group, the healing rate of the dorsal ulcer wound in the PRP intervention group was accelerated, and the expression levels of inflammatory cytokines IL-1β, IL-10, and Conclusions: In this study, ferroptosis was preliminarily verified in DUs at the cellular and animal levels, while PRP could inhibit ferroptosis and significantly improve the migration and regeneration ability of fibroblasts and vascular endothelial cells induced by high glucose.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.