ArticleCell genomics2022
Uncovering novel mutational signatures by
Open access · goldAbstract read
In one paragraph
Article in Cell genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 269 papers.
0numbers the graph read from it
0cells of the map it votes in
269citing papers in PubMed
28.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
269 citing papers in PubMed, 349 citations in OpenAlex.
- Molecular profiling of BRAF-V600E-mutant metastatic colorectal cancer in the phase 3 BEACON CRC trial.Nature medicine · 2024Trial
- Tobacco's dual genomic footprints in bladder cancer revealed by multi-omics analysis: An SBS4-like LumU-enriched signature and smoking-driven HRD-related genomic instability.Genes & diseases · 2026Article
- Article
- Double-base deletions and signatures associated with platinum adducts in metastatic cancer.Nucleic acids research · 2026Article
- Somatic mutations and single-nucleus transcriptomics reveal uniquely human properties of neuronal aging.bioRxiv : the preprint server for biology · 2026Article
- Clonal selection of somatic mutations shapes NK cell memory.bioRxiv : the preprint server for biology · 2026Article
- Article
- Article
- Article
- A complex mutational signature generated by cytarabine resistance.NAR cancer · 2026Article
- The UVA-induced single-base mutational signature of CX-5461 in human cells.Nucleic acids research · 2026Article
- Whole-Exome Sequencing Identifies Candidate Genomic Features Associated with Response to Platinum-Based Chemotherapy and Ixabepilone-Based Treatment in Ovarian Cancer.International journal of molecular sciences · 2026Article
- Identification and validation of a previously missed mutational signature in colorectal cancer.Nature communications · 2026Article
- Article
- Genome instability is increased during DNA replication in the presence of the CPD UV photoproduct in transcriptionally active genes.iScience · 2026Article
- Mutational signature refitting on sparse pan-cancer data.Algorithms for molecular biology : AMB · 2026Article
- Early replication fragile sites are associated with cancer-related CNVs and SNVs in human embryonic stem cells.Stem cell reports · 2026Article
- Variable latency between the founder genetic event and rhabdoid tumor expansion.bioRxiv : the preprint server for biology · 2026Article
- Effects of ethanol and acetaldehyde on multi-organ genomic mutation landscapes.Cell biology and toxicology · 2026Article
- Clonal evolution and mutational trajectories of metastatic colorectal cancer shaped by anticancer therapies.Nature communications · 2026Article
209 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 13 institutions in 5 countries.
S M Ashiqul IslamDepartment of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.
Marcos Díaz-GayDepartment of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.
Yang WuCentre for Computational Biology and Programme in Cancer & Stem Cell Biology, Duke NUS Medical School, Singapore 169857, Singapore.
Mark BarnesDepartment of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.
Raviteja VangaraDepartment of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.
Erik N BergstromDepartment of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.
Yudou HeDepartment of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.
Mike VellaNVIDIA Corporation, 2788 San Tomas Expressway, Santa Clara, CA 95051, USA.
Jingwei WangCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.
Jon W TeagueCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.
Peter ClaphamCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.
Sarah MoodyCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.
Sergey SenkinGenetic Epidemiology Group, International Agency for Research on Cancer, Cedex 08, 69372 Lyon, France.
Yun Rose LiDepartments of Radiation Oncology and Cancer Genetics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Laura RivaCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.
Tongwu ZhangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Andreas J GruberBig Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7LF, UK.
Christopher D SteeleResearch Department of Pathology, Cancer Institute, University College London, London WC1E 6BT, UK.
Burçak OtluDepartment of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.
Azhar KhandekarDepartment of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.
Ammal AbbasiDepartment of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.
Laura HumphreysCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.
Natalia SyulyukinaDepartment of Bioengineering, UC San Diego, La Jolla, CA 92093, USA.
Samuel W BradyDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Boian S AlexandrovTheoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Nischalan PillayResearch Department of Pathology, Cancer Institute, University College London, London WC1E 6BT, UK.
Jinghui ZhangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
David J AdamsCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.
Iñigo MartincorenaCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.
David C WedgeBig Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7LF, UK.
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Paul BrennanGenetic Epidemiology Group, International Agency for Research on Cancer, Cedex 08, 69372 Lyon, France.
Michael R StrattonCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.
Steven G RozenCentre for Computational Biology and Programme in Cancer & Stem Cell Biology, Duke NUS Medical School, Singapore 169857, Singapore.
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.
University of California San Diego · USWellcome Sanger Institute · GBCentre international de recherche sur le cancer · FRDuke-NUS Medical School · SGNational Cancer Institute · USSt. Jude Children's Research Hospital · USCity of Hope · USLos Alamos National Laboratory · USNvidia (United States) · USRoyal National Orthopaedic Hospital · GBUniversity College London · GBUniversity of Konstanz · DEUniversity of Manchester · GB
Funding
Oncology Research Career Development ProgramK12CA001727 · NCI · CITY OF HOPE NATIONAL MEDICAL CENTER · PI MORTIMER, JOANNE E. · 1992 to 2024
$14.6MDetecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer PreventionR01ES032547 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALEXANDROV, LUDMIL B · 2021 to 2025
$3.4MIntegrating epigenomics with DNA breathing dynamics for human non-coding disease variantsR01MH116281 · NIMH · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI ALEXANDROV, BOIAN STOIANOV, DUAN, JUBAO · 2019 to 2023
$3.0MMutational Signatures of a Combined Environmental Exposure: Arsenic and Ultraviolet RadiationR01ES030993 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI HUDSON, LAURIE G, LIU, KE JIAN · 2020 to 2024
$2.5MComprehensive identification of germline-somatic interactionsR01CA269919 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Hannah Kathryn Carter · 2022 to 2026
$2.2MExamining the impact of the obesity-inflammation axis on cancer by genomic and transcriptomic profilingF32CA232635 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LI, YUN ROSE · 2018 to 2020
$202kCancer Research UK 21777Medical Research Council MR/V000292/1NCI NIH HHS F32 CA232635NCI NIH HHS K12 CA001727NCI NIH HHS R01 CA269919NIEHS NIH HHS R01 ES030993NIEHS NIH HHS R01 ES032547NIMH NIH HHS R01 MH116281Wellcome TrustWorld Health Organization 001
Abstract
Mutational signature analysis is commonly performed in cancer genomic studies. Here, we present SigProfilerExtractor, an automated tool for
Indexed as
cancer genomicsgenomicsmutagenesismutational signatures
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.