ArticleMaterials today. Bio2022
An all-silk-derived bilayer hydrogel for osteochondral tissue engineering.
Article in Materials today. Bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Application of Photocrosslinkable Wet-Adhesive Composite Hydrogel Adhesive in Bladder Injury Repair.Bioengineering (Basel, Switzerland) · 2026Article
- Biomass-Derived Hydrogels for Load-Bearing Connective Tissue Repair: Integrative Reinforcement, Bio-Functional Design, and Emerging Pathways Toward Clinical Translation.Advanced healthcare materials · 2026Review
- Pathology-guided design of injectable hydrogels for precision therapy and cartilage regeneration in osteoarthritis.Regenerative biomaterials · 2026Review
- Biofunctionalization of mineralized collagen with platelet-rich plasma enhances osteogenesis in critical-sized bone defects.Frontiers in bioengineering and biotechnology · 2026Article
- Biomimetic bilayer hydrogel coating with antithrombotic and anticalcification properties for cardiovascular tissue engineering application.Regenerative biomaterials · 2026Article
- Hydrogels for Osteochondral Interface Regeneration: Biomaterial Types, Processes, and Animal Models.Gels (Basel, Switzerland) · 2025Review
- Silk Fibroin-Derived Smart Living Hydrogels for Regenerative Medicine and Organoid Engineering: Bioactive, Adaptive, and Clinically Translatable Platforms.Gels (Basel, Switzerland) · 2025Review
- Hydrogel Microspheres as Versatile Platforms for Biomedical Research: Design, Properties, and Applications.MedComm · 2025Review
- Double-Network Bilayer Hydrogel Loaded with Puerarin and Curcumin for Osteochondral Repair.ACS omega · 2025Article
- Bi-phasic integrated silk fibroin/polycaprolactone scaffolds for osteochondral regeneration inspired by the native joint tissue and interface.Materials today. Bio · 2025Article
- Cartilage Tissue Engineering in Multilayer Tissue Regeneration.Annals of biomedical engineering · 2025Review
- Hydrogel-Based Microspheres for Intra-Articular Osteoarthritis Therapy: Multifunctional Carriers for Drug Delivery and Cartilage Repair: A Comprehensive Review.International journal of nanomedicine · 2025Review
- Silk fibroin-based hydrogels for cartilage organoids in osteoarthritis treatment.Theranostics · 2025Review
- Biomimetic multizonal scaffolds for the reconstruction of zonal articular cartilage in chondral and osteochondral defects.Bioactive materials · 2025Review
- Novel injectable adhesive hydrogel loaded with exosomes for holistic repair of hemophilic articular cartilage defect.Bioactive materials · 2024Article
- Application of kartogenin for the treatment of cartilage defects: current practice and future directions.RSC advances · 2024Review
- Amplifying endogenous stem cell migration forMaterials today. Bio · 2024Article
- Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor.Bioactive materials · 2024Article
- Bioactive fiber-reinforced hydrogel to tailor cell microenvironment for structural and functional regeneration of myotendinous junction.Science advances · 2024Article
- Recent Achievements in the Development of Biomaterials Improved with Platelet Concentrates for Soft and Hard Tissue Engineering Applications.International journal of molecular sciences · 2024Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteochondral repair remains a challenge in clinical practice nowadays despite extensive advances in tissue engineering. The insufficient recruitment of endogenous cells in the early stage and incomplete cell differentiation in the later stage constitute the major difficulty of osteochondral repair. Here, a novel all-silk-derived multifunctional biomaterial platform for osteochondral engineering is reported. The bilayer methacrylated silk fibroin (SilMA) hydrogel was fabricated through stratified photocuring as the basic provisional matrix for tissue regeneration. Platelet-rich plasma (PRP) incorporation promoted the migration and pre-differentiation of the bone marrow mesenchymal stem cells (BMSCs) in the early stage of implantation. The long-term regulation of BMSCs chondrogenesis and osteogenesis was realized by the stratified anchoring of the silk fibroin (SF) microspheres respectively loaded with Kartogenin (KGN) and berberine (BBR) in the hydrogel. The composite hydrogels were further demonstrated to promote BMSCs chondrogenic and osteogenic differentiation under an inflammatory microenvironment and to achieve satisfying cartilage and subchondral bone regeneration with great biocompatibility after 8 weeks of implantation. Since all the components used are readily available and biocompatible and can be efficiently integrated via a simple process, this composite hydrogel scaffold has tremendous potential for clinical use in osteochondral regeneration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.