Evidence map›Paper›PMID 36388418›Full record

ArticleNeuro-oncology practice2022

Patterns of care in adult histone mutant gliomas: Results of an international survey.

Alexander Yuile, Mustafa Khasraw, Justin T Low, Kyle M Walsh, Eric Lipp, Joanne Sy, Laveniya Satgunaseelan, Marina Ann Kastelan, Madhawa De Silva, Adrian Lee and 1 more

Abstract read
In one paragraph

Article in Neuro-oncology practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alexander YuileMedical Oncology Department, Royal North Shore Hospital, Sydney, Australia.ORCID https://orcid.org/0000-0002-7242-0528
Mustafa KhasrawThe Preston Robert Tisch Brain Tumor Center, Duke Cancer Institute, Duke University, Durham, USA.ORCID https://orcid.org/0000-0003-3249-9849
Justin T LowThe Preston Robert Tisch Brain Tumor Center, Duke Cancer Institute, Duke University, Durham, USA.
Kyle M WalshThe Preston Robert Tisch Brain Tumor Center, Duke Cancer Institute, Duke University, Durham, USA.
Eric LippThe Preston Robert Tisch Brain Tumor Center, Duke Cancer Institute, Duke University, Durham, USA.
Joanne SyDepartment of Neuropathology, Royal Prince Alfred Hospital, Sydney, Australia.
Laveniya SatgunaseelanDepartment of Neuropathology, Royal Prince Alfred Hospital, Sydney, Australia.
Marina Ann KastelanThe Brain Cancer Group, North Shore Private Hospital, Sydney, Australia.
Madhawa De SilvaMedical Oncology Department, Royal North Shore Hospital, Sydney, Australia.
Adrian LeeMedical Oncology Department, Royal North Shore Hospital, Sydney, Australia.
Helen WheelerMedical Oncology Department, Royal North Shore Hospital, Sydney, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Histone mutant gliomas (HMG) with histone H3 K27 and G34 mutations are recognized as biologically discrete entities with distinct anatomical locations, younger age at presentation (in comparison to the most common high-grade gliomas, IDH wildtype glioblastoma), and poor prognosis. There is a paucity of data regarding the management of adult HMG patients and no consensus on management. This study aims to identify current patterns of Australian and US neuro-oncology clinical practice for this entity. Methods: Following institutional approvals, patterns of care questionnaire designed to capture relevant clinical variables was circulated through the Cooperative Trials Group for Neuro-Oncology (COGNO) in Australia and the Caris Precision Oncology Alliance in the United States (US). Results: Between 4/2021 and 10/2021, 43 responses were collected. 33% ( Conclusion: Here we present a description of how the discovery of a new molecular subtype of primary glial tumors, histone mutated gliomas in adults, is being introduced into clinical practice.

Indexed as

adult histone mutant gliomadiffuse midline gliomaG34K27Mpatterns of care survey

Identifiers

PMID36388418
PMCPMC9665055

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.