Evidence map›Paper›PMID 36388344›Full record

ArticleFrontiers in public health2022

Association between pregnancy and pregnancy loss with COPD in Chinese women: The China Kadoorie Biobank study.

Sha Huang, Jia Yi Hee, Yuxun Oswald Zhang, Ruofan Gongye, Siyu Zou, Kun Tang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Sha HuangVanke School of Public Health, Tsinghua University, Beijing, China.
Jia Yi HeeVanke School of Public Health, Tsinghua University, Beijing, China.
Yuxun Oswald ZhangVanke School of Public Health, Tsinghua University, Beijing, China.
Ruofan GongyeDepartment of Maternal and Child Health, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, United States.
Siyu ZouVanke School of Public Health, Tsinghua University, Beijing, China.
Kun TangVanke School of Public Health, Tsinghua University, Beijing, China.
Vanke (China) · CNTsinghua University · CNUniversity of North Carolina at Chapel Hill · US

Funding

Wellcome TrustWellcome Trust 088158/Z/09/ZWellcome Trust 104085/Z/14/Z
6 · The paper itself

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease characterized by airflow blockage. Pregnancy and pregnancy loss may be related to an elevated risk of COPD, although studies have yet to report on this association. Hence, this study aims to investigate the association between pregnancy and pregnancy loss with the risk of COPD among Chinese women. Methods: Data on 302,510 female participants from the China Kadoorie Biobank were utilized for this study. Multivariable logistic regression, stratified by sociodemographic and lifestyle factors, was employed to obtain the odds ratio (ORs) and 95% confidence intervals (CIs) for the association between pregnancy and pregnancy loss with COPD. Results: Pregnancy loss was significantly associated with increased risk of COPD (OR 1.19, 95% CI 1.13-1.25), specifically, spontaneous (OR 1.19, 95% CI 1.11-1.29) and induced abortion (OR 1.18, 95% CI 1.12-1.25). Stillbirth, however, was not significantly associated with the risk of COPD (OR 1.09, 95% CI 0.99-1.20). Increasing number of pregnancy losses was associated with increasing risk of COPD (one pregnancy loss: OR 1.14, 95% CI 1.07-1.21, two or more pregnancy loss: OR 1.25, 95% CI 1.17-1.32, and each additional pregnancy loss: OR 1.06, 95% CI 1.03-1.09). A single pregnancy was significantly associated with reduced risk of COPD (OR 0.75, 95% CI 0.59-0.97), although each additional pregnancy was significantly associated with increased risk of COPD (OR 1.03, 95% CI 1.01-1.04). Conclusion: Pregnancy loss, in particular, spontaneous and induced abortions are associated with increased risk of COPD among Chinese women. A single pregnancy, however, demonstrated protective effects.

Indexed as

Abortion, InducedAbortion, SpontaneousPulmonary Disease, Chronic ObstructiveBiological Specimen BanksFemaleHumansPregnancyStillbirthCOPDinduced abortionpregnancypregnancy lossspontaneous abortionstillbirth

Identifiers

PMID36388344
PMCPMC9660272
OpenAlexW4307872550

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.