Evidence map›Paper›PMID 36388112›Full record

ArticleFrontiers in physiology2022

Loss of Drosophila Clueless differentially affects the mitochondrial proteome compared to loss of Sod2 and Pink1.

Aditya Sen, Rachel T Cox

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Aditya SenDepartment of Biochemistry and Molecular Biology, Uniformed Services University, Bethesda, MD, United States.
Rachel T CoxDepartment of Biochemistry and Molecular Biology, Uniformed Services University, Bethesda, MD, United States.
Jackson Foundation · USUniformed Services University of the Health Sciences · US

Funding

Clu forms a dynamic new ribonucleoprotein particle directly involved in mitochondrial functionR01GM127938 · NIGMS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI COX, RACHEL TAFEL · 2019 to 2022
$1.3M
NIGMS NIH HHS R01 GM127938
6 · The paper itself

Abstract

Mitochondria contain their own DNA, mitochondrial DNA, which encodes thirteen proteins. However, mitochondria require thousands of proteins encoded in the nucleus to carry out their many functions. Identifying the definitive mitochondrial proteome has been challenging as methods isolating mitochondrial proteins differ and different tissues and organisms may have specialized proteomes. Mitochondrial diseases arising from single gene mutations in nucleus encoded genes could affect the mitochondrial proteome, but deciphering which effects are due to loss of specific pathways or to accumulated general mitochondrial damage is difficult. To identify specific

Indexed as

Cluelessdrosophilamitochondriamitochondrial proteomePINK1respiratory chain complexesSOD2

Identifiers

PMID36388112
PMCPMC9644064
OpenAlexW4307553475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.