Evidence map›Paper›PMID 36387889›Full record

ArticleFrontiers in endocrinology2022

Osteoclast activity sculpts craniofacial form to permit sensorineural patterning in the zebrafish skull.

Kelly Z Miao, Austin Cozzone, Joana Caetano-Lopes, Matthew P Harris, Shannon Fisher

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kelly Z MiaoDepartment of Pharmacology and Experimental Therapeutics, Boston University Aram V. Chobanian & Edward Avedisian School of Medicine, Boston, MA, United States.
Austin CozzoneDepartment of Pharmacology and Experimental Therapeutics, Boston University Aram V. Chobanian & Edward Avedisian School of Medicine, Boston, MA, United States.
Joana Caetano-LopesDepartment of Orthopaedic Surgery, Boston Children's Hospital, Boston, MA, United States.
Matthew P HarrisDepartment of Orthopaedic Surgery, Boston Children's Hospital, Boston, MA, United States.
Shannon FisherDepartment of Pharmacology and Experimental Therapeutics, Boston University Aram V. Chobanian & Edward Avedisian School of Medicine, Boston, MA, United States.
Boston University · USBoston Children's Hospital · US

Funding

TRAINING IN BIOMOLECULAR PHARMACOLOGYT32GM008541 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FARB, DAVID H · 1997 to 2022
$5.2M
Anatomical atlas and transgenic toolkit for late skull formation in zebrafishU01DE024434 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI FISHER, SHANNON, HARRIS, MATTHEW P · 2014 to 2018
$3.3M
Screen for mutations affecting skull and suture formation in zebrafishR01DE022955 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI FISHER, SHANNON · 2013 to 2017
$2.0M
Smad6 deficient zebrafish as a model for multifactorial craniosynostosisR21DE029916 · NIDCR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FISHER, SHANNON · 2021 to 2022
$454k
Medications Prescribed in Emergency Departments for Non-Traumatic Dental ConditioR15DE021196 · NIDCR · MARQUETTE UNIVERSITY · PI OKUNSERI, CHRISTOPHER · 2010 to 2010
$311k
NIDCR NIH HHS R01 DE022955NIDCR NIH HHS R15 DE021196NIDCR NIH HHS R21 DE029916NIDCR NIH HHS U01 DE024434NIGMS NIH HHS T32 GM008541
6 · The paper itself

Abstract

Efforts to understand the morphogenesis of complex craniofacial structures have largely focused on the role of chondrocytes and osteoblasts. Along with these bone-creating cells, bone-resorbing osteoclasts are critical in homeostasis of adult skeletal structures, but there is currently limited information on their role in the complex morphogenetic events of craniofacial development. Fundamental aspects of skull formation and general skeletal development are conserved from zebrafish to mammals. Using a

Indexed as

OsteoclastsZebrafishAnimalsBone DevelopmentHeadHumansMammalsSkullcraniofacial developmentforamenlateral linelive imagingneuromastosteoclastzebrafish

Identifiers

PMID36387889
PMCPMC9664155
OpenAlexW4307757483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.