ArticleFrontiers in endocrinology2022
The spoke wheel color Doppler blood flow signal is a specific sign of papillary thyroid carcinoma.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 11 citations in OpenAlex.
- Analysis of features of papillary thyroid carcinoma on color Doppler ultrasound images: implications for lymph node metastasis.BMC medical imaging · 2025Article
- Multimodal ultrasound features for distinguishing classic and aggressive subtypes of papillary thyroid carcinoma.Frontiers in endocrinology · 2025Article
- Application of microvascular ultrasound-assisted thyroid imaging report and data system in thyroid nodule risk stratification.Insights into imaging · 2024Article
- Application of color doppler ultrasound and US shear wave elastography with connective tissue growth factor in the risk assessment of papillary thyroid carcinoma.BMC medical imaging · 2024Article
- Diagnostic value of circulating tumor cells in patients with thyroid cancer: a retrospective study of 1478 patients.Discover oncology · 2024Article
- Quantitative ultrasound imaging parameters in patients with cancerous thyroid nodules: development of a diagnostic model.American journal of translational research · 2024Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
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Abstract
Background: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Grayscale ultrasound (US) is the main method used to diagnose benign and malignant thyroid nodules, While color doppler blood flow imaging(CDFI) is not widely recognized when diagnosing thyroid cancer. Methods: This study used a retrospective analysis. The study included 36 spoked wheel blood flow nodules detected by CDFI in 37,372 patients in five hospitals from January 2020 to June 2021. All thyroid nodules were examined histologically after ultrasound-guided fine needle biopsy or following surgical resection. The value of color doppler in diagnosing papillary thyroid carcinoma was evaluated based on pathological results. Results: Among 36 thyroid nodules, only 6 were highly suspected of being malignant on grayscale ultrasound (classified as 5, according to ACR TI-RADS). However, these 36 thyroid nodules showed spoke wheel blood flow signal distribution on CDFI. If the spoke wheel blood flow signal is used to diagnose papillary thyroid cancer, then the diagnostic accuracy of this group of papillary thyroid cancers can reach 100%, which is significantly higher than the accuracy of grayscale ultrasound diagnosis, and the difference is statistically significant (p<0.05). Conclusions: The results of this study found that spoke wheel blood flow sign on CDFI can be used to diagnose PTC. PTC with spoke wheel blood flow have benign characteristics on gray-scale ultrasound, which is easy to be misdiagnosed.
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