Evidence map›Paper›PMID 36387880›Full record

ArticleFrontiers in endocrinology2022

Comparison of serum cytokines levels in normal-weight and overweight patients with first-episode drug-naïve major depressive disorder.

Wenfan Gao, Yayun Xu, Jun Liang, Yanhong Sun, Yuanyuan Zhang, Feng Shan, Jinfang Ge, Qingrong Xia

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Wenfan GaoAffiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Yayun XuDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
Jun LiangAffiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Yanhong SunAffiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Yuanyuan ZhangAffiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Feng ShanAffiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Jinfang GeInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, Anhui Medical University, Hefei, China.
Qingrong XiaAffiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Anhui Mental Health Center · CNAnhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Abnormal levels of blood cytokines have been demonstrated to be associated with both excess weight and major depressive disorder (MDD). However, few studies have addressed the direct effect of body mass index (BMI) on basal serum cytokines in individuals with first-episode drug-naïve MDD. Methods: A total of 49 patients with first-episode drug-naïve MDD were categorized into normal weight (18.5 ≤ BMI < 25 kg/m Results: The scores of HAMD-24 in overweight group were significantly higher than normal weight group ( Conclusions: These results provide direct evidence, probably for the first time, that overweight may be associated with several serum cytokines in patients with first-episode drug-naïve MDD. The underlying mechanisms are unclear and require further investigation.

Indexed as

CytokinesMajor Depressive DisorderHumansIntercellular Adhesion Molecule-1Interleukin 1 Receptor Antagonist ProteinInterleukin-3OverweightTumor Necrosis Factor-alphaCytokinesIntercellular Adhesion Molecule-1Interleukin 1 Receptor Antagonist ProteinInterleukin-3Tumor Necrosis Factor-alphabody mass indexcytokinesmajor depressive disorderoverweightserum

Identifiers

PMID36387880
PMCPMC9647627
OpenAlexW4307631031

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.