ReviewHeliyon2022
Is the insula linked to sleep? A systematic review and narrative synthesis.
Review in Heliyon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Insomnia as a Behavioral Pathway from Fear of Missing Out to Depression in Emerging Adults.Brain sciences · 2025Article
- Article
- Article
- Cerebellar-limbic dysregulation and sensorimotor network alterations in male primary insomnia: a resting-state functional magnetic resonance imaging study.Frontiers in human neuroscience · 2025Article
- Insomnia in Forensic Detainees: Is Salience Network the Common Pathway for Sleep, Neuropsychiatric, and Neurodegenerative Disorders?Journal of clinical medicine · 2024Review
- Insula Connectivity Abnormalities Predict Impulsivity in Chronic Heroin Use Disorder: A Cross-Sectional Resting-State fMRI Study.Brain sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sleep is critical to human beings in a surprisingly diverse set of ways, and there is, thus, continual investigation into the mechanisms of sleep. Although current studies have confirmed that multiple brain regions are involved in the regulation of both sleep and wakefulness, the association between certain important brain regions such as the insula and sleep is still unclear. Objective: The purpose of this study was to systematically review studies on the insula and sleep and to discuss the relationship between the insula and sleep. Methods: We searched the PubMed and Web of Science Core Collection (WoSCC) for articles on sleep and the insula. The time span was from inception to June 30, 2022. The search results were then narratively summarized. Results: A total of 939 studies were identified in the PubMed and WoSCC of which 115 studies were finally included in the narrative synthesis. These 115 studies can be roughly divided into 41 studies on insomnia, 39 on sleep deprivation, 33 on sleep-related experiments examining the insula, and 2 studies using basic experiments. Conclusion: The combined findings of many sleep-related studies have confirmed a close link between the insula and sleep loss, including insomnia, sleep deprivation, sleep-related disorders, and more. Although these results do not directly confirm that the insula is involved in sleep, a overall analysis of the results indicates that the insula may be a potential key brain region involved in sleep.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.