Evidence map›Paper›PMID 36387339›Full record

ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2022

Celastrol and Rhynchophylline in the mitigation of simulated muscle atrophy under

Maksymilian Wastag, Katarzyna Bieżuńska-Kusiak, Anna Szewczyk, Wojciech Szlasa, Bożena Grimling, Julita Kulbacka

Open access · hybridAbstract read
In one paragraph

Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maksymilian WastagFaculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556, Wroclaw, Poland.
Katarzyna Bieżuńska-KusiakDepartment of Molecular and Cellular Biology, Wroclaw Medical University, Borowska 211A 50-556, Wroclaw, Poland.
Anna SzewczykDepartment of Molecular and Cellular Biology, Wroclaw Medical University, Borowska 211A 50-556, Wroclaw, Poland.
Wojciech SzlasaFaculty of Medicine, Wroclaw Medical University, Pasteura 1, 50-367 Wroclaw, Poland.
Bożena GrimlingDepartment of Drug Form Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland.
Julita KulbackaDepartment of Molecular and Cellular Biology, Wroclaw Medical University, Borowska 211A 50-556, Wroclaw, Poland.
Wroclaw Medical University · PLUniversity of Wrocław · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Muscular atrophy (MA) is a disease of various origins, i.e., genetic or the most common, caused by mechanical injury. So far, there is no universal therapeutic model because this disease is often progressive with numerous manifested symptoms. Moreover, there is no safe and low-risk therapy dedicated to muscle atrophy. For this reason, our research focuses on finding an alternative method using natural compounds to treat MA. This study proposes implementing natural substances such as celastrol and Rhynchophylline on the cellular level, using a simulated and controlled atrophy process.

Indexed as

Akt1, serine/threonine-protein kinase or AKT kinase 1CelastrolCLS, celastrolDEX, dexamethasoneDOX, doxorubicinERK1/2, extracellular signal-regulated kinase 1/2HSF1, Heat shock factor 1HSP, heat shock proteinICC, immunocytochemistryMAFbx, Muscle Atrophy F-box geneMA, Muscular atrophyMMP, mitochondrial membrane potentialmPTP, mitochondrial permeability transition poreMTCO1, Mitochondrially Encoded Cytochrome C Oxidase IMTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideMuRF1, Muscle RING Finger protein-1Muscle atrophyNLS, nuclear localization signalsRA, rheumatoid arthritisRhynchophyllineRyn, RhynchophyllineSkeletal musclesSMA, spinal muscular atrophyVDAC, voltage-dependent anion channel

Identifiers

PMID36387339
PMCPMC9649342
OpenAlexW4283256935

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.