Evidence map›Paper›PMID 36387295›Full record

ArticleAJOG global reports2022

Patterns of pregnancy loss among women living with and without HIV in Brazil, 2008-2018.

Lanbo Yang, Mary Catherine Cambou, Eddy R Segura, Marineide Gonçalves De Melo, Breno Riegel Santos, Ivana Rosângela Dos Santos Varella, Karin Nielsen-Saines

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJOG global reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Lanbo YangWarren Alpert Medical School, Brown University, Providence, RI (Dr Lanbo Yang).
Mary Catherine CambouDivision of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA (Drs Mary Catherine Cambou, and Eddy R. Segura).
Eddy R SeguraDivision of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA (Drs Mary Catherine Cambou, and Eddy R. Segura).
Marineide Gonçalves De MeloHospital Nossa Senhora da Conceição, Sistéma Único de Saúde, Porto Alegre, Brazil (Drs Marineide Gonçalves De Melo, Breno Riegel Santos, and Ivana Rosngela Dos Santos Varella).
Breno Riegel SantosHospital Nossa Senhora da Conceição, Sistéma Único de Saúde, Porto Alegre, Brazil (Drs Marineide Gonçalves De Melo, Breno Riegel Santos, and Ivana Rosngela Dos Santos Varella).
Ivana Rosângela Dos Santos VarellaHospital Nossa Senhora da Conceição, Sistéma Único de Saúde, Porto Alegre, Brazil (Drs Marineide Gonçalves De Melo, Breno Riegel Santos, and Ivana Rosngela Dos Santos Varella).
Karin Nielsen-SainesDivision of Pediatric Infectious Diseases, Department of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA (Dr Karin Nielsen-Saines).
Hospital Nossa Senhora da Conceição · BRUniversity of California, Los Angeles · USBrown University · US

Funding

UCLA AIDS Prevention and Treatment Clinical Trials UnitUM1AI069424 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Judith S. Currier, RAPHAEL J LANDOVITZ · 2012 to 2026
$51.8M
South American Program in HIV Prevention Research (SAPHIR)R25MH087222 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JESSE LAWTON CLARK, Karin Nielsen · 2011 to 2026
$3.9M
NIAID NIH HHS UM1 AI069424NIMH NIH HHS R25 MH087222
6 · The paper itself

Abstract

backgroundPregnancy loss is poorly understood, but infection may be a risk factor. Few studies have evaluated pregnancy loss among women living with HIV in the era of potent combination antiretroviral therapy.

objectiveWe hypothesize that maternal HIV and syphilis infection lead to increased risk of pregnancy loss, including both miscarriage and stillbirth. This study aimed to assess trends and possible predictors of spontaneous miscarriage and stillbirth among women living with HIV in a cohort of nearly 56,000 deliveries at a major referral institution in a city with the highest prevalence of HIV in Brazil. STUDY

designData from hospital records for women delivering from January 1, 2008 to December 31, 2018 were reviewed. Rates of stillbirth, miscarriage, and any pregnancy loss were compared using the Pearson chi-square test. Predictors of pregnancy loss were evaluated by robust univariate log-linear Poisson regression using a generalized estimating equations approach.

resultsA total of 55,844 pregnancies were included in the analysis, with 54,308 pregnancies from 43,502 women without HIV and 1536 pregnancies from 1186 women living with HIV (seroprevalence of maternal HIV: 2.7%). Overall, 1130 stillbirths (2.0%) and 6558 miscarriages (11.7%) occurred. Any pregnancy loss was similar in both groups (13.8% in women without and 14.1% in women with HIV;

conclusionIn the era of combination antiretroviral therapy, there was no difference in miscarriage rates between women with and without HIV. HIV was associated with stillbirth risk but improved over time. Maternal syphilis was significantly associated with any pregnancy loss and stillbirth in all women. Syphilis is likely the main driver of pregnancy loss in women living with HIV in Brazil.

Indexed as

adverse pregnancy outcomecoinfectionHIVmiscarriagepregnancy lossstillbirthsyphilis

Identifiers

PMID36387295
PMCPMC9643582
OpenAlexW4306643735

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.