Evidence map›Paper›PMID 36387254›Full record

ArticleFrontiers in oncology2022

Association between vessels that encapsulate tumour clusters vascular pattern and hepatocellular carcinoma recurrence following liver transplantation.

Claude Dennis, David S Prince, Leila Moayed-Alaei, Devika Remash, Emily Carr-Boyd, David G Bowen, Simone I Strasser, Michael Crawford, Carlo Pulitano, James Kench and 3 more

Abstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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  5. Preliminary study on the ability ofQuantitative imaging in medicine and surgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Claude DennisAustralian National Liver Transplant Unit, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
David S PrinceDepartment of Gastroenterology, Liverpool Hospital, Sydney, NSW, Australia.
Leila Moayed-AlaeiNew South Wales Health Pathology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Devika RemashAustralian National Liver Transplant Unit, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Emily Carr-BoydDepartment of Histopathology, Auckland District Health Board LabPlus, Auckland, New Zealand.
David G BowenAustralian National Liver Transplant Unit, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Simone I StrasserAustralian National Liver Transplant Unit, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Michael CrawfordAustralian National Liver Transplant Unit, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Carlo PulitanoAustralian National Liver Transplant Unit, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
James KenchNew South Wales Health Pathology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Geoffrey W McCaughanAustralian National Liver Transplant Unit, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Catriona McKenzieNew South Wales Health Pathology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Ken LiuAustralian National Liver Transplant Unit, Royal Prince Alfred Hospital, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vessels that encapsulate tumor clusters (VETC) is a novel vascular pattern seen on hepatocellular carcinoma (HCC) histology which has been shown to independently predict tumor recurrence and survival after liver resection. Its prognostic value in HCC patients receiving liver transplantation (LT) is unclear. Methods: We retrospectively studied consecutive adults who underwent deceased-donor LT with active HCC found on explant between 2010-2019. Tumor tissue was stained for CD34 and quantified for VETC. Primary and secondary endpoints were time to recurrence (TTR) and recurrence-free survival (RFS). Results: During the study period, 158 patients received LT where HCC was present on explant. VETC pattern was seen in 76.5% of explants. Patients with VETC-positive tumors spent longer on the waitlist (6.4 vs. 4.1 months, Conclusion: VETC pattern is commonly observed in HCC patients undergoing LT. The number of VETC-positive tumors, but not its presence, is an independent risk factor for TTR and RFS post-LT.

Indexed as

explant pathologyimmunosuppressionmetastasestumor recurrencetumor vasculaturevessels that encapsulate tumor clusters

Identifiers

PMID36387254
PMCPMC9643778

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.