ArticleFrontiers in oncology2022
Prediction of breast cancer-related lymphedema risk after postoperative radiotherapy
Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Efficacy of physical therapy for prevention and treatment of postoperative lymphedema in breast cancer: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Epidemiological and Clinical Risk Factors for Breast Cancer-Related Lymphedema: A Case-Control Study From Hamadan, Western Iran.BioMed research international · 2026Article
- Impact of chemotherapy on breast cancer-related lymphedema: a retrospective study.Frontiers in oncology · 2026Article
- Factors affecting the formation of lymphedema due to breast cancer (Is primary systemic treatment an independent factor in the formation of breast cancer related lymphedema?).Turkish journal of surgery · 2025Article
- Optimizing Lymphedema Management After Breast Cancer: Predictive Risk Models in Clinical Practice.Journal of surgical oncology · 2025Article
- Postoperative cholesterol changes as early predictors of breast cancer-related lymphedema: a retrospective cohort study.Breast cancer (Tokyo, Japan) · 2025Article
- Letter to the editor: "Association between chemotherapy and the risk of developing breast cancer-related lymphedema: a nationwide retrospective cohort study".Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Nomogram for predicting risk of arm lymphedema following axillary lymph node dissection in breast cancer patients.Frontiers in oncology · 2025Article
- Impact of neoadjuvant chemotherapy on breast cancer-related lymphedema after axillary lymph node dissection: a retrospective cohort study.Breast cancer research and treatment · 2024Article
- Breast Cancer-Related Lymphedema (BCRL) and Bioimpedance Spectroscopy: Long-Term Follow-Up, Surveillance Recommendations, and Multidisciplinary Risk Factors.Annals of surgical oncology · 2023Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: We identified novel clinical and dosimetric prognostic factors affecting breast cancer-related lymphedema after postoperative radiotherapy (RT) and developed a multivariable logistic regression model to predict lymphedema in these patients. Methods and materials: In total, 580 patients with unilateral breast cancer were retrospectively reviewed. All patients underwent breast surgery and postoperative RT with or without systemic treatment in 2015. Among the 580 patients, 532 with available RT plan data were randomly divided into training (n=372) and test (n=160) cohorts at a 7:3 ratio to generate and validate the lymphedema prediction models, respectively. An area under the curve (AUC) value was estimated to compare models. Results: The median follow-up duration was 5.4 years. In total, 104 (17.9%) patients experienced lymphedema with a cumulative incidence as follows: 1 year, 10.5%; 3 years, 16.4%; and 5 years, 17.6%. Multivariate analysis showed that body mass index ≥25 kg/m Conclusions: Our study demonstrated that a shorter interval from surgery to RT and other established clinical factors were associated with increased lymphedema risk. By combining these factors with two dosimetric parameters, we propose a multivariable logistic regression model for breast cancer-related lymphedema prediction after RT.
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