Evidence map›Paper›PMID 36386785›Full record

ReviewFrontiers in behavioral neuroscience2022

Neurobiological mechanisms of mood disorders: Stress vulnerability and resilience.

Clairton Marcolongo-Pereira, Fernanda Cristina de Abreu Quintela Castro, Rafael Mazioli Barcelos, Kelly Cristina Mota Braga Chiepe, Joamyr Victor Rossoni Junior, Roberta Passamani Ambrosio, Orlando Chiarelli-Neto, Ana Paula Pesarico

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Lifetime adversity exposure, mood symptoms, and immune mitochondrial bioenergetics.medRxiv : the preprint server for health sciences · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. From Stress to Synapse: The Neuronal Atrophy Pathway to Mood Dysregulation.International journal of molecular sciences · 2025
    Review
  8. Review
  9. Review
  10. Circulating long noncoding RNA: New frontiers in biomarker research for mood disorders.Genomic psychiatry : advancing science from genes to society · 2025
    Article
  11. Article
  12. Article
  13. Effects of aNutrients · 2023
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Clairton Marcolongo-PereiraCoordenadoria de Pesquisa, Pós-Graduação e Extensão (CEPEG), Centro Universitário do Espírito Santo (UNESC), Colatina, Brazil.
Fernanda Cristina de Abreu Quintela CastroCoordenadoria de Pesquisa, Pós-Graduação e Extensão (CEPEG), Centro Universitário do Espírito Santo (UNESC), Colatina, Brazil.
Rafael Mazioli BarcelosCoordenadoria de Pesquisa, Pós-Graduação e Extensão (CEPEG), Centro Universitário do Espírito Santo (UNESC), Colatina, Brazil.
Kelly Cristina Mota Braga ChiepeCoordenadoria de Pesquisa, Pós-Graduação e Extensão (CEPEG), Centro Universitário do Espírito Santo (UNESC), Colatina, Brazil.
Joamyr Victor Rossoni JuniorCoordenadoria de Pesquisa, Pós-Graduação e Extensão (CEPEG), Centro Universitário do Espírito Santo (UNESC), Colatina, Brazil.
Roberta Passamani AmbrosioCoordenadoria de Pesquisa, Pós-Graduação e Extensão (CEPEG), Centro Universitário do Espírito Santo (UNESC), Colatina, Brazil.
Orlando Chiarelli-NetoCoordenadoria de Pesquisa, Pós-Graduação e Extensão (CEPEG), Centro Universitário do Espírito Santo (UNESC), Colatina, Brazil.
Ana Paula PesaricoCurso de Medicina, Universidade Federal do Pampa (Unipampa), Bagé, Brazil.
Centro Universitário do Espírito Santo · BRUniversidade Federal do Pampa · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress is an important factor in the development of several human pathologies. The response of rodents and humans to stress depends on many factors; some people and rodents develop stress-related mood disorders, such as depression and anxiety in humans, depression-like and anxiety-like behavior in mice and rats, while others report no new psychological symptoms in response to chronic or acute stress, and are considered susceptible and resilient to stress, respectively. Resilience is defined as the ability to thrive in the face of adversity and is a learned process that can help protect against occupational stressors and mental illnesses. There is growing interest in the underlying mechanisms involved in resilience and vulnerability to depression caused by stress, and some studies have demonstrated that individual variability in the way animals and humans respond to stress depends on several mechanisms, such as oxidative stress, neuronal plasticity, immunology and genetic factors, among others not discussed in this review, this review provides a general overview about this mechanism.

Indexed as

anxietydepressionresiliencestressvulnerability

Identifiers

PMID36386785
PMCPMC9650072
OpenAlexW4307705776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.