Evidence map›Paper›PMID 36386719›Full record

ReviewFrontiers in microbiology2022

Hemorrhagic fever viruses: Pathogenesis, therapeutics, and emerging and re-emerging potential.

Lizdany Flórez-Álvarez, Edmarcia Elisa de Souza, Viviane Fongaro Botosso, Danielle Bruna Leal de Oliveira, Paulo Lee Ho, Carlos Pelleschi Taborda, Giuseppe Palmisano, Margareth Lara Capurro, João Renato Rebello Pinho, Helena Lage Ferreira and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Article
  4. Article
  5. Article
  6. CD4Nature immunology · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Lizdany Flórez-ÁlvarezInstitute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Edmarcia Elisa de SouzaInstitute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Viviane Fongaro BotossoVirology Laboratory, Butantan Institute, São Paulo, Brazil.
Danielle Bruna Leal de OliveiraAlbert Einstein Institute for Teaching and Research (IIEP), Hospital Israelita Albert Einstein, São Paulo, Brazil.
Paulo Lee HoVirology Laboratory, Butantan Institute, São Paulo, Brazil.
Carlos Pelleschi TabordaInstitute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Giuseppe PalmisanoInstitute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Margareth Lara CapurroInstitute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
João Renato Rebello PinhoAlbert Einstein Institute for Teaching and Research (IIEP), Hospital Israelita Albert Einstein, São Paulo, Brazil.
Helena Lage FerreiraFaculty of Animal Science and Food Engineering, University of São Paulo, São Paulo, Brazil.
Paola MinoprioScientific Platform Pasteur-USP, São Paulo, Brazil.
Eurico ArrudaFaculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Luís Carlos de Souza FerreiraInstitute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Carsten WrengerInstitute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Edison Luiz DurigonInstitute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Universidade Cidade de São Paulo · BRUniversidade de São Paulo · BRHospital Israelita Albert Einstein · BRInstituto Butantan · BR

Funding

Controlling Arbovirus Transmission: PopulationSuppression and Virus-Induced Mosquito DeathR01AI149608 · NIAID · TEXAS A&M AGRILIFE RESEARCH · PI ADELMAN, ZACH N., CAPURRO GUIMARAES, MARGARETH DE LARA · 2020 to 2023
$669k
NIAID NIH HHS R01 AI149608
6 · The paper itself

Abstract

Hemorrhagic fever viruses (HFVs) pose a threat to global public health owing to the emergence and re-emergence of highly fatal diseases. Viral hemorrhagic fevers (VHFs) caused by these viruses are mostly characterized by an acute febrile syndrome with coagulation abnormalities and generalized hemorrhage that may lead to life-threatening organ dysfunction. Currently, the events underlying the viral pathogenicity associated with multiple organ dysfunction syndrome still underexplored. In this minireview, we address the current knowledge of the mechanisms underlying VHFs pathogenesis and discuss the available development of preventive and therapeutic options to treat these infections. Furthermore, we discuss the potential of HFVs to cause worldwide emergencies along with factors that favor their spread beyond their original niches.

Indexed as

emergingfatal viral diseasehemorrhagic fever virusesre-emerging infectious diseasesviral hemorrhagic fevers

Identifiers

PMID36386719
PMCPMC9640979
OpenAlexW4307370593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.