ArticleJournal of inflammation research2022
Associations of Inflammation with Risk of Cardiovascular and All-Cause Mortality in Adults with Hypertension: An Inflammatory Prognostic Scoring System.
Article in Journal of inflammation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Metabolic Inflammation as a Common Thread in Cardio-Endocrine Diseases: Toward a Unified Therapeutic Framework.Cureus · 2026Review
- Development and validation of a logistic regression-based nomogram for predicting 1-year all-cause death and heart failure rehospitalization in hypertensive patients with chronic heart failure.Frontiers in cardiovascular medicine · 2026Article
- Cardiovascular risk stratification in inflammatory-driven conditions: how far have we come?Frontiers in cardiovascular medicine · 2026Review
- Clinical parameters-based machine learning models for predicting intraoperative hemodynamic instability in hypertensive pheochromocytomas and paragangliomas patients.World journal of urology · 2025Article
- Vitamin D as a Key Mediator Between C-reactive Protein to Albumin Ratio and Congestive Heart Failure in an Elderly Population: An Innovative Exploration Using the NHANES Database.Reviews in cardiovascular medicine · 2025Article
- Endothelial Activation and Stress Index Predicts All-Cause and Cardiovascular Mortality in Hypertensive Individuals: A Nationwide Study.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- IDH-mutant glioma risk stratification via whole slide images: Identifying pathological feature associations.iScience · 2025Article
- Inflammatory Biomarkers in Hypertension.Current medicinal chemistry · 2025Review
- Article
- Elevated monocyte-to-lymphocyte ratio, C-reactive protein and further inflammatory parameters as potential biomarkers of suicide risk in bipolar I disorder.Frontiers in psychiatry · 2025Article
- Associations between sarcopenia (defined by low muscle mass), inflammatory markers, and all-cause mortality in older adults: mediation analyses in a large U.S. NHANES community sample, 1999-2006.Frontiers in medicine · 2025Article
- Elevated Platelet-to-Lymphocyte Ratio as a Predictor of All-Cause and Cardiovascular Mortality in Hypertensive Individuals.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- An inflammatory prognostic scoring system to predict the risk for adults with acute coronary syndrome undergoing percutaneous coronary intervention.BMC cardiovascular disorders · 2024Article
- Association between inflammatory biomarkers and hypertension among sedentary adults in US: NHANES 2009-2018.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Prediction of Osteoporotic Hip Fracture Outcome: Comparative Accuracy of 27 Immune-Inflammatory-Metabolic Markers and Related Conceptual Issues.Journal of clinical medicine · 2024Article
- Association of neutrophil-to-lymphocyte ratio and risk of cardiovascular and all-cause mortality in hypertension patients.Heliyon · 2024Article
- Neutrophil-to-lymphocyte ratio as a predictor of all-cause and cardiovascular mortality in coronary heart disease and hypertensive patients: a retrospective cohort study.Frontiers in endocrinology · 2024Article
- Do Interleukin-1 and Interleukin-6 Antagonists Hold Any Place in the Treatment of Atherosclerotic Cardiovascular Disease and Related Co-Morbidities? An Overview of Available Clinical Evidence.Journal of clinical medicine · 2023Review
- Associations of complete blood cell count-derived inflammatory biomarkers with asthma and mortality in adults: a population-based study.Frontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
12 authors.
Funding
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Abstract
Background: Inflammation is one of the major pathways in the progression of hypertension (HTN), and the related inflammatory markers have demonstrated certain predictive values. The current study aimed to integrate these markers to construct an inflammatory prognostic scoring (IPS) system and to assess the prognostic values of IPS in patients with HTN. Methods: A total of 9846 adult participants with HTN from NHANES 1999-2010 were enrolled and followed up. Demographic characteristics and the related laboratory results for the 12 inflammatory markers were collected. LASSO-COX regression, Kaplan-Meier, restricted cubic spline COX regression (RCS), receiver operator characteristic curve (ROC), and random survival forests (RSF) analysis were applied to explore the values of individual and IPS parameters. Results: At the census date of follow-up, 2387 (24.2%) were identified as all-cause deaths and 484 (4.9%) as cardiovascular deaths. All inflammatory markers showed certain prognostic values. Then, based on the LAASO analysis, LDH, ALP, LYM, NLR, MLR, SIRI, and RDW were included in the construction of the IPS system. The higher IPS had significantly worse long-term prognosis in Kaplan-Meier analysis ( Conclusion: Our results highlight that a higher IPS (system integrating the inflammatory markers) was associated with the increased risk of cardiovascular and all-cause mortality in patients with HTN, suggesting that IPS is a useful method for risk stratification in HTN.
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