Evidence map›Paper›PMID 36386584›Full record

ReviewJournal of inflammation research2022

Vagus Nerve and Underlying Impact on the Gut Microbiota-Brain Axis in Behavior and Neurodegenerative Diseases.

Yimin Han, Boya Wang, Han Gao, Chengwei He, Rongxuan Hua, Chen Liang, Sitian Zhang, Ying Wang, Shuzi Xin, Jingdong Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of inflammation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yimin Han *Department of Oral Medicine, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, People's Republic of China.
Boya Wang *Undergraduate Student of 2018 Eight Program of Clinical Medicine, Peking University People's Hospital, Beijing, 100083, People's Republic of China.ORCID 0000-0003-4771-1785
Han GaoDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, People's Republic of China.
Chengwei HeDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, People's Republic of China.
Rongxuan HuaDepartment of Clinical Medicine, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, People's Republic of China.ORCID 0000-0003-4315-4731
Chen LiangDepartment of Clinical Medicine, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, People's Republic of China.
Sitian ZhangDepartment of Clinical Medicine, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, People's Republic of China.
Ying WangDepartment of Dermatology, Beijing Tong Ren Hospital, Capital Medical University, Beijing, 100069, People's Republic of China.
Shuzi XinDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, People's Republic of China.
Jingdong XuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, People's Republic of China.ORCID 0000-0003-4546-563X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota is the most abundant and diverse microbiota in the human body and the vagus nerve is the most widely distributed and complex nerve in the body, both of them are essential in maintaining homeostasis. The most important phenomenon is how they coordinate to regulate functions, which has attracted the great attention of scientists. The academic literature on the correlation with a host of intestinal diseases and even systemic diseases has revealed the bidirectional communication between the gut microbiota and the brain, which can be carried out via multiple patterns. In the review, firstly, we have a general overview of the gut microbiota and the gut microbiota-brain axis. Secondly, according to the distribution characteristics of the vagus nerve, we analyzed and summarized its function in the intestinal tract. At the same time, we have summarized the underlying mechanism of some behavior changes such as depressive and anxiety-like behaviors and related neurodegenerative diseases caused by the vagus nerve and intestinal microecological environment disorders, and then we also analyzed inconsistency of the experimental evidence in order to propose novel strategies for the clinical practice.

Indexed as

behaviorbraingut microbiotagut microbiota-brain axisneurodegenerative diseasesvagus nerve

Identifiers

PMID36386584
PMCPMC9656367

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.