Evidence map›Paper›PMID 36386564›Full record

Article3 Biotech2022

Molecular docking and antimalarial evaluation of novel

Nayana Adhikari, Ayesha Aktar Khanam Choudhury, Anshul Shakya, Surajit Kumar Ghosh, Saurav Jyoti Patgiri, Udaya Pratap Singh, Hans Raj Bhat

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in 3 Biotech, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Nayana AdhikariDepartment of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam 786004 India.
Ayesha Aktar Khanam ChoudhuryDepartment of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam 786004 India.
Anshul ShakyaDepartment of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam 786004 India.
Surajit Kumar GhoshDepartment of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam 786004 India.
Saurav Jyoti PatgiriRegional Medical Research Centre, Indian Council of Medical Research (ICMR), Dibrugarh, Assam 786001 India.
Udaya Pratap SinghDrug Design and Discovery Laboratory, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, Uttar Pradesh 211007 India.
Hans Raj BhatDepartment of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam 786004 India.ORCID 0000-0002-9643-4916
Dibrugarh University · INIndian Council of Medical Research · INSam Higginbottom Institute of Agriculture · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria has been a source of concern for humans for millennia; therefore in the present study we have utilized in-silico approach to generate diverse anti-malarial hit. Towards this, Molinspiration cheminformatics and Biovia Discovery Studio (DS) 2020 were used to conduct molecular modelling studies on 120 designed compounds. Furthermore, the TOPKAT module was used to evaluate the toxicity of the screened compounds. The CDOCKER docking technology was used to investigate protein-ligand docking against the Supplementary Information: The online version contains supplementary material available at 10.1007/s13205-022-03400-2.

Indexed as

1,3,5-triazineAntimalarialDockingMolecular dynamicsN-(4-aminobenzoyl)-l-glutamic acidPf-DHFR-TS

Identifiers

PMID36386564
PMCPMC9649585
OpenAlexW4308710304

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.