ArticleInfection and drug resistance2022
Bioassay-Guided Phytochemical Analyses and Antimicrobial Potentials of the Leaf Extract of
Article in Infection and drug resistance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- In vitro antibacterial properties of selected medicinal plants used by traditional healers for gastrointestinal disorders in the Heban-Arsi and Kofale districts of Southern Ethiopia.BMC complementary medicine and therapies · 2026Article
- Alternative Approaches and Plant-Based Remedies for Livestock Health Management Among the Batswana of Southern Africa: A Review.Chemistry & biodiversity · 2026Review
- In vitro antimicrobial potential and phytochemical analysis of root extracts of Rumex abyssinicus from southern Ethiopia.PloS one · 2026Article
- Article
- Antibacterial Activity Against Multidrug-Resistant Clinical Isolates of Nine Plants from Chencha, Southern Ethiopia.Infection and drug resistance · 2023Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In spite of the great advances in modern medicine in recent decades, medicines of plant origin are still in use for several ailments in different parts of the world. There is always an urge to develop novel, effective and inexpensive antimicrobials. This study was aimed to evaluate the antimicrobial activity and phytochemical composition of the leaf extract of Methods: The crude extracts of Results: A varying patterns of antimicrobial activity against tested microorganism was observed. Acetone extract showed the highest spectrum of activity (17-32mm) in the well diffusion assay against bacteria and 16-23mm in the case of fungi. The MIC ranged from 7.5-60 mg/mL in the case of bacteria and 15-60 mg/mL against fungi. The bioassay-guided column chromatography of the acetone extract followed by GC-MS showed the presence of three major compounds, specifically O-ethylhydroxylamine (43%), 2-ethyl heptanoic acid (20.6%), and 1-nonyl cycloheptane (19.5%). The finding was confirmed by FT-IR and elemental analysis of TLC-separated fractions. Conclusion: The acetone extract showed better antimicrobial activity and the least minimum inhibition concentrations against bacteria compared to fungi. The observed antibacterial can be assigned to the presence of alkoxy amine, alkyl aliphatic acids, and cycloalkane. The overall findings substantiate the traditional usages of the parts of this plant, especially the leaves, in managing infectious diseases.
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