Evidence map›Paper›PMID 36386306›Full record

ArticleFrontiers in cardiovascular medicine2022

First quantitative dosages: Strong correlations between non-5-HT

Olivier Schussler, Luc Maroteaux, Ramadan Jashari, Pierre Falcoz, Marco Alifano, Yves Lecarpentier, Jean-Marie Launay

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Olivier SchusslerResearch Laboratory, Department of Cardiovascular Surgery, Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland.
Luc MaroteauxINSERM UMR-S 1270, Paris, France.
Ramadan JashariEuropean Homograft Bank, Brussels, Belgium.
Pierre FalcozDepartment of Thoracic Surgery, Nouvel Hôpital Civil, Hôpitaux de Strasbourg, Strasbourg, France.
Marco AlifanoAP-HP Centre, Université de Paris, Hôpital Cochin, Service Thoracique, Paris, France.
Yves LecarpentierCentre de Recherche Clinique, Grand Hôpital de l'Est Francilien, Meaux, France.
Jean-Marie LaunayINSERM-S 942, Centre for Biological Resources BB-0033-00064, University Paris, Hôpital Lariboisière, APHP, Paris, France.
Inserm · FRHôpital Civil, Strasbourg · FRHôpital Cochin · FRNational Bank of Belgium · BEUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Although critical in animal and human development and pathology, a measurement of the quantitative expression of 5-HTR serotonin receptors on animal or human valvular tissues has never been performed. Methods: Quantification of the most frequent 5-HTRs reported as being present in human peripheral tissue was performed using radiolabeled agonists/antagonists. A membrane protein extract from normal human valves (aortic/mitral/tricuspid and some pulmonary) and associated diseased left myocardium, all unusable in clinics, were obtained from the Homograft bank. Results: We analyzed 5-HT Conclusion: 5-HT

Indexed as

heart valve diseasehuman heart valvesquantitative expressionserotonin 5-HTserotonin receptor 5-HTRsvalvular degeneration

Identifiers

PMID36386306
PMCPMC9641165
OpenAlexW4307370826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.