Evidence map›Paper›PMID 36386297›Full record

ArticlePhotoacoustics2022

Assessment of prostate cancer progression using a translational needle photoacoustic sensing probe: Preliminary study with intact human prostates

Linyu Ni, Wei-Kuan Lin, Amy Kasputis, Deborah Postiff, Javed Siddiqui, Matthew J Allaway, Matthew S Davenport, John T Wei, Jay L Guo, Todd M Morgan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photoacoustics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Imprinted high-Opto-electronic advances · 2026
    Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Linyu NiDepartment of Biomedical Engineering, University of Michigan, 500 S. State St., Ann Arbor, 48109, MI, USA.
Wei-Kuan LinDepartment of Electrical Engineering and Computer Sciences, University of Michigan, 500 S. State St., Ann Arbor, 48109, MI, USA.
Amy KasputisDepartment of Urology, University of Michigan, 500 S. State St., Ann Arbor, 48109, MI, USA.
Deborah PostiffDepartment of Pathology, University of Michigan, 500 S. State St., Ann Arbor, 48109, MI, USA.
Javed SiddiquiDepartment of Pathology, University of Michigan, 500 S. State St., Ann Arbor, 48109, MI, USA.
Matthew J AllawayPerineologic, 183 N Centre Street, Cumberland, 21502, Md, USA.
Matthew S DavenportDepartment of Urology, University of Michigan, 500 S. State St., Ann Arbor, 48109, MI, USA.
John T WeiDepartment of Urology, University of Michigan, 500 S. State St., Ann Arbor, 48109, MI, USA.
Jay L GuoDepartment of Electrical Engineering and Computer Sciences, University of Michigan, 500 S. State St., Ann Arbor, 48109, MI, USA.
Todd M MorganDepartment of Urology, University of Michigan, 500 S. State St., Ann Arbor, 48109, MI, USA.
Aaron M UdagerMichigan Center for Translational Pathology, Rogel Cancer Center, Department of Pathology, University of Michigan, 500 S. State St., Ann Arbor, 48109, MI, USA.
Xueding WangDepartment of Biomedical Engineering, University of Michigan, 500 S. State St., Ann Arbor, 48109, MI, USA.
Guan XuDepartment of Biomedical Engineering, University of Michigan, 500 S. State St., Ann Arbor, 48109, MI, USA.

Funding

Measuring Molecular and Mechanical Outcomes of Endoscopic Dilation of Fibrotic StricturesR01DK125687 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Peter D.R. Higgins, Guan Xu · 2020 to 2026
$3.3M
Real time fine needle assessment of architectural heterogeneity in prostate cancerR37CA222829 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, GUAN · 2019 to 2025
$3.2M
NCI NIH HHS R37 CA222829NIDDK NIH HHS R01 DK125687
6 · The paper itself

Abstract

In our previous studies, we demonstrated the ability of an interstitial all-optical needle photoacoustic (PA) sensing probe and PA spectral analysis (PASA) to assess the aggressiveness of prostate cancer. In this clinical translation investigation, we integrated the optical components of the needle PA sensing probe into a 18G steel needle. The translational needle PA sensing probe was evaluated using intact human prostates in a simulated ultrasound-guided transperineal prostate biopsy. PA signals were acquired at 1220 nm, 1370 nm, 800 nm and 266 nm at each interstitial measurement location and quantified by PASA within the frequency range of 8-28 MHz. The measurement locations were stained for establishing spatial correlations between the quantitative measurements and the histological diagnosing. Most of the quantitative PA assessments reveal statistically significant differences between the benign and cancerous regions. Multivariate analysis combining the PASA quantifications shows an accuracy close to 90% in differentiating the benign and cancerous regions in the prostates.

Indexed as

Photoacoustic spectral analysisProstate cancerThe translational photoacoustic sensing needle probe

Identifiers

PMID36386297
PMCPMC9650056

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.