Evidence map›Paper›PMID 36386295›Full record

ArticlePhotoacoustics2022

Investigation of silk as a phantom material for ultrasound and photoacoustic imaging.

Christopher D Nguyen, Skye A Edwards, Tyler W Iorizzo, Brooke N Longo, Anna N Yaroslavsky, David L Kaplan, Srivalleesha Mallidi

Open access · goldAbstract read
In one paragraph

Article in Photoacoustics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Christopher D NguyenDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
Skye A EdwardsDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
Tyler W IorizzoDepartment of Physics, University of Massachusetts Lowell, Lowell, MA 01854 USA.
Brooke N LongoDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
Anna N YaroslavskyDepartment of Physics, University of Massachusetts Lowell, Lowell, MA 01854 USA.
David L KaplanDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
Srivalleesha MallidiDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
Tufts University · USUniversity of Massachusetts Lowell · US

Funding

Image-guided oxygen enhanced photodynamic therapy with multi-functional nanodroplets to improve head and neck cancer treatment outcomesR01CA266701 · NCI · TUFTS UNIVERSITY MEDFORD · PI Srivalleesha Mallidi · 2022 to 2026
$1.7M
Biodegradable liquid metal nanoagents for photoacoustic image-guided photodynamic therapyR21CA263694 · NCI · TUFTS UNIVERSITY MEDFORD · PI MALLIDI, SRIVALLEESHA · 2022 to 2023
$399k
NCI NIH HHS R01 CA266701NCI NIH HHS R21 CA263694
6 · The paper itself

Abstract

Comprehensive characterization of biomedical imaging systems require phantoms that are easy to fabricate and can mimic human tissue. Additionally, with the arrival of engineered tissues, it is key to develop phantoms that can mimic bioengineered samples. In ultrasound and photoacoustic imaging, water-soluble phantom materials such as gelatin undergo rapid degradation while polymer-based materials such as polyvinyl alcohol are not conducive for generating bioengineered tissues that can incorporate cells. Here we propose silk protein-based hydrogels as an ultrasound and photoacoustic phantom material that has potential to provide a 3D environment for long-term sustainable cell growth. Common acoustic, optical, and biomechanical properties such as ultrasound attenuation, reduced scattering coefficient, and Young's modulus were measured. The results indicate that silk acoustically mimics many tissue types while exhibiting similar reduced optical scattering in the wavelength range of 400-1200 nm. Furthermore, silk-based materials can be stored long-term with no change in acoustic and optical properties, and hence can be utilized to assess the performance of ultrasound and photoacoustic systems.

Indexed as

Acoustic attenuationOptical absorptionOptical scatteringPhantom materialPhotoacoustic imagingSilkSpeed of soundUltrasound imaging

Identifiers

PMID36386295
PMCPMC9649953
OpenAlexW4304959473

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.