Evidence map›Paper›PMID 36386292›Full record

ArticlePhotoacoustics2022

Early diagnosis of bladder cancer by photoacoustic imaging of tumor-targeted gold nanorods.

Elisa Alchera, Matteo Monieri, Mirko Maturi, Irene Locatelli, Erica Locatelli, Silvia Tortorella, Angelina Sacchi, Angelo Corti, Manuela Nebuloni, Roberta Lucianò and 9 more

Abstract read
In one paragraph

Article in Photoacoustics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
  3. PD1-IL2v expands and induces effector CD8Journal of experimental & clinical cancer research : CR · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Review
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  9. Piezo1/ITGB1 Synergizes With CaCancer medicine · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Gold nanorod-assisted theranostic solution for nonvisible residual disease in bladder cancer.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Elisa AlcheraUnit of Urology, URI, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Matteo MonieriTumor Biology and Vascular Targeting Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Mirko MaturiDepartment of Industrial Chemistry "Toso Montanari", University of Bologna, Bologna, Italy.
Irene LocatelliUnit of Urology, URI, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Erica LocatelliDepartment of Industrial Chemistry "Toso Montanari", University of Bologna, Bologna, Italy.
Silvia TortorellaDepartment of Industrial Chemistry "Toso Montanari", University of Bologna, Bologna, Italy.
Angelina SacchiTumor Biology and Vascular Targeting Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Angelo CortiTumor Biology and Vascular Targeting Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Manuela NebuloniPathology Unit, Department of Biomedical and Clinical Sciences, L. Sacco Hospital, Università degli Studi di Milano, Milan, Italy.
Roberta LucianòDepartment of Pathology, IRCCS San Raffaele Hospital and Scientific Institute, Milan, Italy.
Filippo PederzoliUnit of Urology, URI, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Francesco MontorsiUnit of Urology, URI, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Andrea SaloniaUnit of Urology, URI, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Sandra MeyerFUJIFILM Visualsonics Inc., Amsterdam, the Netherlands.
Jithin JoseFUJIFILM Visualsonics Inc., Amsterdam, the Netherlands.
Pierangela GiustettoFreedom Waves s.r.l., Milan, Italy.
Mauro Comes FranchiniDepartment of Industrial Chemistry "Toso Montanari", University of Bologna, Bologna, Italy.
Flavio CurnisTumor Biology and Vascular Targeting Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Massimo AlfanoUnit of Urology, URI, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Detection and removal of bladder cancer lesions at an early stage is crucial for preventing tumor relapse and progression. This study aimed to develop a new technological platform for the visualization of small and flat urothelial lesions of high-grade bladder carcinoma in situ (CIS). We found that the integrin α5β1, overexpressed in bladder cancer cell lines, murine orthotopic bladder cancer and human bladder CIS, can be exploited as a receptor for targeted delivery of GNRs functionalized with the cyclic CphgisoDGRG peptide (

Indexed as

Bladder cancerEarly diagnosisGold nanorodsPhotoacoustic imagingTumor targeting

Identifiers

PMID36386292
PMCPMC9649962

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.