ArticleOpen forum infectious diseases2022
Clinical and Radiologic Factors Associated With Detection of
Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A clinical prediction model for rapidly differentiating pulmonary tuberculosis from community acquired pneumonia in children.Italian journal of pediatrics · 2025Article
- Culturing stool specimens has no added value in diagnosing pulmonary tuberculosis.Journal of clinical tuberculosis and other mycobacterial diseases · 2024Article
- Gendered gaps to tuberculosis prevention and care in Kenya: a political economy analysis study.BMJ open · 2024Article
- Machine learning to predict bacteriologic confirmation of Mycobacterium tuberculosis in infants and very young children.PLOS digital health · 2023Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pediatric tuberculosis (TB) remains a critical public health concern, yet bacteriologic confirmation of TB in children is challenging. Clinical, demographic, and radiological factors associated with a positive Methods: We conducted a prospective cohort study of young children with presumptive TB and examined clinical, demographic, and radiologic factors associated with invasive and noninvasive specimen collection techniques (gastric aspirate, induced sputum, nasopharyngeal aspirate, stool, and string test); up to 2 samples were taken per child, per technique. We estimated associations between these factors and a positive specimen for each technique using generalized estimating equations (GEEs) and logistic regression. Results: A median (range) of 544 (507-566) samples were obtained for each specimen collection technique from 300 enrolled children; bacteriologic yield was low across all collection techniques (range, 1%-7% from Xpert MTB/RIF or culture), except for lymph node fine needle aspiration (29%) taken for children with cervical lymphadenopathy. Factors associated with positive Conclusions: Identifying factors that lead to a positive
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