Evidence map›Paper›PMID 36385934›Full record

ArticleACS medicinal chemistry letters2022

Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode.

Stacey M Southall, Joydeep Banerjee, Jason Brown, Kristina Butkovic, Andrew D Cansfield, Julie E Cansfield, Miles S Congreve, Gabriella Cseke, Francesca Deflorian, Martina Petrovic Hunjadi and 5 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Stacey M SouthallSosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom.
Joydeep BanerjeeSyngene International, Biocon Park, Bommasandra, Bangalore, Karnataka 560099, India.
Jason BrownSosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom.
Kristina ButkovicSelvita d.o.o., Prilaz aruna Filipovića 29, 10000 Zagreb, Croatia.
Andrew D CansfieldSosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom.
Julie E CansfieldSosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom.
Miles S CongreveSosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom.
Gabriella CsekeSosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom.
Francesca DeflorianSosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom.
Martina Petrovic HunjadiSelvita d.o.o., Prilaz aruna Filipovića 29, 10000 Zagreb, Croatia.
Antun HutinecSelvita d.o.o., Prilaz aruna Filipovića 29, 10000 Zagreb, Croatia.
Trinadh Kumar InturiSyngene International, Biocon Park, Bommasandra, Bangalore, Karnataka 560099, India.
Renata RupcicSelvita d.o.o., Prilaz aruna Filipovića 29, 10000 Zagreb, Croatia.
Gordon SaxtySelvita d.o.o., Prilaz aruna Filipovića 29, 10000 Zagreb, Croatia.
Stephen P WatsonSosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom.ORCID https://orcid.org/0000-0003-1451-964X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The diastereomeric macrocyclic calcitonin gene-related peptide (CGRP) antagonists HTL0029881 (

Identifiers

PMID36385934
PMCPMC9661699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.