Evidence map›Paper›PMID 36385707›Full record

ArticleCancer2023

Combination of Deauville score and quantitative positron emission tomography parameters as a predictive tool of anti-CD19 chimeric antigen receptor T-cell efficacy.

Anna Guidetti, Anna Dodero, Alice Lorenzoni, Sara Pizzamiglio, Giovanni Argiroffi, Annalisa Chiappella, Filippo Bagnoli, Vincenzo Marasco, Cristiana Carniti, Chiara Monfrini and 5 more

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06339255 (A Multicenter Prospective Observational Study on Chimeric Antigen Receptor), which is not on this map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06339255 recruitingnot on this map

A Multicenter Prospective Observational Study on Chimeric Antigen Receptor (CAR) T-cell Therapy for Lymphoma: Monitoring Feasibility, Efficacy, Toxicity and Biomarkers in a Real Life Setting

TypeobservationalSponsorPaolo CorradiniRan2019 to 2029Enrolled5,300ConditionsDiffuse Low Grade B-Cell Lymphoma, Primary Mediastinal Large B-cell Lymphoma (PMBCL), Mantle Cell Lymphoma, Follicular Lymphoma
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. The prognostic utility ofFrontiers in immunology · 2024
    Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Review
  8. [European journal of radiology open · 2025
    Article
  9. Article
  10. Review
  11. Prognostic Value ofKorean journal of radiology · 2024
    Article
  12. CAR T-cell therapy in aggressive lymphomas-identifying prognostic and predictive markers.Hematology. American Society of Hematology. Education Program · 2023
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Anna GuidettiDepartment of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.ORCID 0000-0002-4195-6397
Anna DoderoDepartment of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Alice LorenzoniNuclear Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Sara PizzamiglioDepartment of Applied Research and Technological Development, Unit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Giovanni ArgiroffiNuclear Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.ORCID 0000-0002-0928-2927
Annalisa ChiappellaDepartment of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Filippo BagnoliDepartment of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.ORCID 0000-0003-2371-6952
Vincenzo MarascoDepartment of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Cristiana CarnitiDepartment of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.ORCID 0000-0003-1039-1757
Chiara MonfriniDepartment of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Ettore SeregniNuclear Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Martina PennisiDepartment of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Paolo VerderioDepartment of Applied Research and Technological Development, Unit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Alessandra AlessiNuclear Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Paolo CorradiniDepartment of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Fondazione IRCCS Istituto Nazionale dei Tumori · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy is an effective treatment for approximately 40% of relapsed/refractory large B cell lymphomas (LBCL), and early identification of patients at risk for relapse or progression after CAR T-cell therapy represents a clinical need.

methodsThe authors conducted a single-center prospective study on 47 relapsed/refractory LBCL receiving CAR T-cell therapy to evaluate the prognostic value of baseline and after infusion

resultsDeep variation of standardized uptake value (SUV)

conclusionsPET parameters and association of DS and variation of SUV LAY SUMMARY: This is a single-center prospective study on 47 lymphoma patients receiving commercial chimeric antigen receptor T-cell therapy aimed to evaluate the prognostic value of baseline and after infusion

Indexed as

Lymphoma, B-CellLymphoma, Large B-Cell, DiffuseReceptors, Chimeric AntigenFluorodeoxyglucose F18HumansNeoplasm Recurrence, LocalPositron-Emission TomographyPositron Emission Tomography Computed TomographyPrognosisProspective StudiesRetrospective StudiesT-LymphocytesFluorodeoxyglucose F18Receptors, Chimeric AntigenCAR T-cellDeauville scorelymphomaPETSUV

Identifiers

PMID36385707
PMCPMC10099560
OpenAlexW4309243032

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.