Evidence map›Paper›PMID 36385611›Full record

ArticlePharmacological reports : PR2023

The effects of the recurrent social isolation stress on fear extinction and dopamine D

Aleksandra Wisłowska-Stanek, Małgorzata Lehner, Filip Tomczuk, Aleksandra Gawryluk, Karolina Kołosowska, Anna Sułek, Paweł Krząśnik, Alicja Sobolewska, Adriana Wawer, Adam Płaźnik and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacological reports : PR, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Aleksandra Wisłowska-StanekDepartment of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology (CEPT), Medical University of Warsaw, 1B Banacha Street, 02-097, Warsaw, Poland. awislowska@wum.edu.pl.ORCID http://orcid.org/0000-0001-5657-1089
Małgorzata LehnerDepartment of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02-957, Warsaw, Poland.
Filip TomczukDepartment of Genetics, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02-957, Warsaw, Poland.
Aleksandra GawrylukLaboratory of Neuroplasticity, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Street, 02-093, Warsaw, Poland.
Karolina KołosowskaDepartment of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02-957, Warsaw, Poland.
Anna SułekDepartment of Genetics, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02-957, Warsaw, Poland.
Paweł KrząśnikDepartment of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology (CEPT), Medical University of Warsaw, 1B Banacha Street, 02-097, Warsaw, Poland.
Alicja SobolewskaDepartment of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02-957, Warsaw, Poland.
Adriana WawerDepartment of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology (CEPT), Medical University of Warsaw, 1B Banacha Street, 02-097, Warsaw, Poland.
Adam PłaźnikDepartment of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02-957, Warsaw, Poland.
Anna SkórzewskaDepartment of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02-957, Warsaw, Poland.
Institute of Psychiatry and Neurology · PLMedical University of Warsaw · PLInstytut Biologii Doświadczalnej im. Marcelego Nenckiego · PL

Funding

Narodowe Centrum Nauki 2018/28/C/NZ7/00240
6 · The paper itself

Abstract

backgroundThe present study assessed the influence of recurrent social isolation stress on the aversive memory extinction and dopamine D

methodsMale adult fear-conditioned rats had three episodes of 48 h social isolation stress before each fear extinction session in weeks intervals. Ninety minutes after the last extinction session, the D

resultsIt was found that recurrent social isolation stress decreased the fear extinction rate. The extinguished isolated rats were characterized by higher expression of D

conclusionsOur results suggest that social isolation stress impairs aversive memory extinction and coexists with changes in the D

Indexed as

FearMicroRNAsReceptors, Dopamine D2AmygdalaAnimalsExtinction, PsychologicalHippocampusMaleRatsMicroRNAsMIRN142 microRNA, ratReceptors, Dopamine D2AmygdalaDopamine D2 receptorsFear extinctionHippocampusSocial isolation

Identifiers

PMID36385611
PMCPMC9889440
OpenAlexW4309247014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.