ArticleNature2022
Enterococci enhance Clostridioides difficile pathogenesis.
Open access · greenAbstract read
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers.
0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed
20.6field-weighted citation impact, top 1% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
152 citing papers in PubMed, 210 citations in OpenAlex.
- Fecal filtrate transplantation as salvage therapy for fulminantGut microbes · 2026Trial
- 15-strain live biotherapeutic product or same donor fecal microbiota transplant for recurrent Clostridioides difficile infection: a randomized phase 1b trial.Nature medicine · 2026Trial
- Experimental human colonisation with non-toxigenic Clostridioides difficile: a placebo-controlled randomised clinical trial.Nature communications · 2026Trial
- Review
- Gut microbiota-driven IL-17A production by hepatic γδ T cells enhances neutrophil defense against systemicVirulence · 2026Article
- Arginine metabolism as a mutualistic strategy in the interaction between Porphyromonas gingivalis and Filifactor alocis.Nature communications · 2026Article
- Review
- A programmed reset mechanism primesScience advances · 2026Article
- A regulator of amino acid catabolism controls Acinetobacter baumannii gut colonization.Nature communications · 2026Article
- Combining genotoxic gut bacterial strains increases tumor burden and accelerates onset in a germ-free mouse model of colon carcinogenesis.Cell reports · 2026Article
- Environmental formermSystems · 2026Article
- Phase variable colony morphotypes ofInfection and immunity · 2026Article
- Review
- Ecological and dietary strategies to constrain Clostridioides difficile.Cell host & microbe · 2026Review
- Integrated multi-dimensional modeling of non-model bacteria identifies engineering targets for acarbose biosynthesis optimization.Cell reports methods · 2026Article
- Carbadox, a veterinary growth promoter exhibits anticlostridial activity through induction of oxidative stress in Clostridioides difficile.Gut pathogens · 2026Article
- Acidification-dependent suppression ofInfection and immunity · 2026Article
- The Role of Gut Microbiota in Acute Myeloid Leukemia.Journal of clinical medicine · 2026Review
- Contact dependent suppression ofbioRxiv : the preprint server for biology · 2026Article
- Article
92 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 7 institutions in 1 country.
Alexander B SmithDivision of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-5407-0141
Matthew L JeniorDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
Orlaith KeenanDivision of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jessica L HartDivision of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jonathan SpeckerDepartment of Chemistry, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-6481-4412
Arwa AbbasDivision of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Paula C RangelDivision of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Chao DiDepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jamal GreenDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Katelyn A BustinDepartment of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8933-9825
Jennifer A GaddyDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Maribeth R NicholsonDepartment of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA.
Clare LautDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Brendan J KellyDepartment of Medicine, Division of Infectious Diseases & Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2023-646X
Megan L MatthewsDepartment of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1178-4616
Daniel R EvansDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA, USA.
Daria Van TyneDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-7284-0103
Emma E FurthDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jason A PapinDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-2769-5805
Frederic D BushmanDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-4740-4056
Jessi ErlichmanDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Robert N BaldassanoDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michael A SilvermanDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Gary M DunnyDepartment of Microbiology, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-9436-9006
Boone M PrenticeDepartment of Chemistry, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-1927-9457
Eric P SkaarDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Joseph P ZackularDivision of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA. joseph.zackular@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-3228-3055
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · USVanderbilt University · USUniversity of Florida · USUniversity of Pittsburgh · USUniversity of Virginia · USUniversity of Minnesota Medical Center · US
Funding
Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MTRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI REBECCA G WELLS · 1997 to 2026
$32.5MTRAINING PROGRAM IN CELL AND MOLECULAR BIOLOGYT32GM007229 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 1985 to 2023
$14.0MEnhanced Detection System for Healthcare-Associated Transmission of InfectionR01AI127472 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRISON, LEE H · 2016 to 2025
$7.6MMolecular mapping of microbial communities at the host-pathogen interface by multi-modal 3-dimensional imaging mass spectrometryR01AI138581 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric P Skaar, Jeffrey M Spraggins · 2018 to 2026
$5.2MDefining the impact of host factors on the molecular architecture and bacterial physiology of Staphylococcus aureus abscessesR01AI145992 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASSAT, JAMES E, SKAAR, ERIC P · 2020 to 2024
$3.8MPredoctoral Training at the Chemistry-Biology InterfaceT32GM071339 · NIGMS · WISTAR INSTITUTE · PI MARMORSTEIN, RONEN, SPEICHER, DAVID W. · 2005 to 2019
$3.2MAdaptation of vancomycin-resistant enterococci during bloodstream infectionR01AI165519 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VAN TYNE, DARIA N · 2022 to 2025
$3.0MMolecular interactions in the gut microbiota during early life colonization and perturbationR35GM138369 · NIGMS · CHILDREN'S HOSP OF PHILADELPHIA · PI Joseph Paul Zackular · 2020 to 2026
$2.7MMAOI-inspired activity probes to translate epigenetics and genetics into drugsDP1DA051620 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI MATTHEWS, MEGAN L · 2020 to 2024
$2.5MDetermining the contribution of zinc deficiency to perinatal Group B Streptococcus infectionsR01HD090061 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARONOFF, DAVID M, GADDY, JENNIFER A · 2017 to 2021
$2.5MNCATS NIH HHS UL1 TR000445NCCIH NIH HHS R01 AT010253NIAID NIH HHS K23 AI121485NIAID NIH HHS P30 AI045008NIAID NIH HHS R01 AI127472NIAID NIH HHS R01 AI138581NIAID NIH HHS R01 AI145992NIAID NIH HHS R01 AI164587NIAID NIH HHS R01 AI165519NICHD NIH HHS R01 HD090061NIDA NIH HHS DP1 DA051620NIDDK NIH HHS P30 DK050306NIGMS NIH HHS R35 GM138369NIGMS NIH HHS T32 GM007229NIGMS NIH HHS T32 GM071339
Abstract
Enteric pathogens are exposed to a dynamic polymicrobial environment in the gastrointestinal tract
Indexed as
Clostridioides difficileEnterococcusMicrobial InteractionsAnimalsAnti-Bacterial AgentsArginineDisease Models, AnimalDisease SusceptibilityDrug Resistance, BacterialGastrointestinal MicrobiomeHumansIntestinesLeucineMiceOrnithineVirulenceAnti-Bacterial AgentsArginineLeucineOrnithine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.