Evidence map›Paper›PMID 36385486›Full record

ArticleScientific reports2022

Development of a deep learning method for improving diagnostic accuracy for uterine sarcoma cases.

Yusuke Toyohara, Kenbun Sone, Katsuhiko Noda, Kaname Yoshida, Ryo Kurokawa, Tomoya Tanishima, Shimpei Kato, Shohei Inui, Yudai Nakai, Masanori Ishida and 19 more

Abstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Yusuke ToyoharaDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-Ku, Tokyo, 113-8655, Japan.
Kenbun SoneDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-Ku, Tokyo, 113-8655, Japan. ksone5274@gmail.com.
Katsuhiko NodaSIOS Technology, Inc., Tokyo, Japan.
Kaname YoshidaSIOS Technology, Inc., Tokyo, Japan.
Ryo KurokawaDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Tomoya TanishimaDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Shimpei KatoDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Shohei InuiDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yudai NakaiDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Masanori IshidaDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Wataru GonoiDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Saki TanimotoDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-Ku, Tokyo, 113-8655, Japan.
Yu TakahashiDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-Ku, Tokyo, 113-8655, Japan.
Futaba InoueDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-Ku, Tokyo, 113-8655, Japan.
Asako KukitaDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-Ku, Tokyo, 113-8655, Japan.
Yoshiko KawataDepartment of Obstetrics and Gynecology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Ayumi TaguchiDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-Ku, Tokyo, 113-8655, Japan.
Akiko FurusawaDepartment of Obstetrics and Gynecology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Yuichiro MiyamotoDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-Ku, Tokyo, 113-8655, Japan.
Takehiro TsukazakiDepartment of Obstetrics and Gynecology, Showa General Hospital, Tokyo, Japan.
Michihiro TanikawaDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-Ku, Tokyo, 113-8655, Japan.
Takayuki IriyamaDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-Ku, Tokyo, 113-8655, Japan.
Mayuyo Mori-UchinoDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-Ku, Tokyo, 113-8655, Japan.
Tetsushi TsurugaDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-Ku, Tokyo, 113-8655, Japan.
Katsutoshi OdaDivision of Integrative Genomics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Toshiharu YasugiDepartment of Obstetrics and Gynecology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Kimihiro TakechiDepartment of Obstetrics and Gynecology, Showa General Hospital, Tokyo, Japan.
Osamu AbeDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yutaka OsugaDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-Ku, Tokyo, 113-8655, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uterine sarcomas have very poor prognoses and are sometimes difficult to distinguish from uterine leiomyomas on preoperative examinations. Herein, we investigated whether deep neural network (DNN) models can improve the accuracy of preoperative MRI-based diagnosis in patients with uterine sarcomas. Fifteen sequences of MRI for patients (uterine sarcoma group: n = 63; uterine leiomyoma: n = 200) were used to train the models. Six radiologists (three specialists, three practitioners) interpreted the same images for validation. The most important individual sequences for diagnosis were axial T2-weighted imaging (T2WI), sagittal T2WI, and diffusion-weighted imaging. These sequences also represented the most accurate combination (accuracy: 91.3%), achieving diagnostic ability comparable to that of specialists (accuracy: 88.3%) and superior to that of practitioners (accuracy: 80.1%). Moreover, radiologists' diagnostic accuracy improved when provided with DNN results (specialists: 89.6%; practitioners: 92.3%). Our DNN models are valuable to improve diagnostic accuracy, especially in filling the gap of clinical skills between interpreters. This method can be a universal model for the use of deep learning in the diagnostic imaging of rare tumors.

Indexed as

Deep LearningLeiomyomaPelvic NeoplasmsSarcomaSoft Tissue NeoplasmsUterine NeoplasmsDiagnosis, DifferentialFemaleHumansSensitivity and Specificity

Identifiers

PMID36385486
PMCPMC9669038

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.