ArticleEpilepsia2023
Responsive neurostimulation with low-frequency stimulation.
Article in Epilepsia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Responsive neurostimulation in pediatric epilepsy: a systematic review and individual patient meta-analysis supplemented by a single institution case series in 105 aggregated patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Pooled it
- Optimizing stimulation parameters for anterior thalamic nuclei deep brain stimulation in epilepsy: A randomized crossover trial.Epilepsia · 2025Trial
- A guide to neuromodulation in drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026Review
- Corticocortical evoked potential amplitude is altered by cortical stimulation in epilepsy.Epilepsia · 2026Article
- Safety of Intracranial Neuromodulation in Drug-Resistant Pediatric and Adult Epilepsy.Neurology · 2026Article
- 50 Hz Cortical stimulation increases interictal epileptiform discharges at the seizure onset zone.Brain communications · 2026Article
- Significant seizure frequency reduction in a patient with refractory bitemporal epilepsy following transition from high-frequency to low-frequency responsive neurostimulation.Epilepsy & behavior reports · 2025Article
- Electroceuticals for Motherhood: Utility of responsive neurostimulation and Proactive antiseizure medication management in two pregnancies.Epilepsy & behavior reports · 2025Article
- Neurostimulation in Childhood Epilepsy.Indian pediatrics · 2025Review
- Invasive Neurostimulation for the Treatment of Epilepsy.Seminars in neurology · 2025Review
- On brain stimulation in epilepsy.Brain : a journal of neurology · 2025Review
- Kilohertz electrical stimulation evokes robust cellular responses like conventional frequencies but distinct population dynamics.Communications biology · 2025Article
- Intracranial closed-loop neuromodulation as an intervention for neuropsychiatric disorders: an overview.Frontiers in psychiatry · 2025Review
- Bilateral pulvinar responsive neurostimulation for bilateral multifocal posteriorly dominant drug resistant epilepsy.Epilepsia open · 2024Article
- Electroencephalographic source imaging of spikes with concurrent high-frequency oscillations is concordant with the clinical ground truth.Epilepsia · 2024Article
- Emergent responsive neurostimulation in pediatric super-refractory epilepsia partialis continua.Annals of clinical and translational neurology · 2024Article
- Bilateral centromedian nucleus of thalamus responsive neurostimulation for pediatric-onset drug-resistant epilepsy.Epilepsia · 2024Article
- Safety and efficacy of a novel responsive neurostimulation system in China for drug-refractory focal epilepsy: The first-in-man study.Chinese medical journal · 2024Article
- Current state of the epilepsy drug and device pipeline.Epilepsia · 2024Review
- Stimulation to probe, excite, and inhibit the epileptic brain.Epilepsia · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Deep brain stimulation and responsive neurostimulation (RNS) use high-frequency stimulation (HFS) per the pivotal trials and manufacturer-recommended therapy protocols. However, not all patients respond to HFS. In this retrospective case series, 10 patients implanted with the RNS System were programmed with low-frequency stimulation (LFS) to treat their seizures; nine of these patients were previously treated with HFS (100 Hz or greater). LFS was defined as frequency < 10 Hz. Burst duration was increased to at least 1000 ms. With HFS, patients had a median seizure reduction (MSR) of 13% (interquartile range [IQR] = -67 to 54) after a median of 19 months (IQR = 8-49). In contrast, LFS was associated with a 67% MSR (IQR = 13-95) when compared to HFS and 76% MSR (IQR = 43-91) when compared to baseline prior to implantation. Charge delivered per hour and pulses per day were not significantly different between HFS and LFS, although time stimulated per day was longer for LFS (228 min) than for HFS (7 min). There were no LFS-specific adverse effects reported by any of the patients. LFS could represent an alternative, effective method for delivering stimulation in focal drug-resistant epilepsy patients treated with the RNS System.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.