Evidence map›Paper›PMID 36385439›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2023

A Highly Efficacious Electrical Biofilm Treatment System for Combating Chronic Wound Bacterial Infections.

Fan Zhao, Yajuan Su, Junying Wang, Svetlana Romanova, Dominick J DiMaio, Jingwei Xie, Siwei Zhao

Open access · greenAbstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 75 citations in OpenAlex.

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  12. HJournal of nanobiotechnology · 2025
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  18. Nanozymes for Accelerating the Foot Wound Healing: A Review.International journal of nanomedicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Fan ZhaoMary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Yajuan SuMary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Junying WangMary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Svetlana RomanovaDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Dominick J DiMaioDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Jingwei XieMary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Siwei ZhaoMary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.ORCID https://orcid.org/0000-0003-3516-9968
Nebraska Medical Center · USUniversity of Nebraska Medical Center · US

Funding

Nebraska Center for Nanomedicine- Pilot ProjectsP30GM127200 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI OUPICKY, DAVID · 2018 to 2022
$5.7M
Novel Janus-type Antimicrobial Dressings for the Treatment of Biofilms in Chronic WoundsR01GM138552 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, GUANGSHUN, XIE, JINGWEI · 2020 to 2023
$2.2M
A Hydrogel Ionic Circuit-Based Electrical Stimulation System for Restoration of Denervated Muscles After Peripheral Nerve InjuriesR21AR078439 · NIAMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DUAN, BIN, ZHAO, SIWEI · 2021 to 2022
$378k
A Novel High-Intensity Iontophoresis-Based Antibiotic Delivery Device for Efficacious Eradication of Chronic Wound BiofilmsR21AR080906 · NIAMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI XIE, JINGWEI, ZHAO, SIWEI · 2022 to 2023
$367k
COBRE Nebraska Center for NanomedicineNIAMS NIH HHS R21 AR078439NIAMS NIH HHS R21 AR080906NIGMS NIH HHS NIAMS R21 AR078439NIGMS NIH HHS NIAMS R21 AR080906NIGMS NIH HHS NIGMS R01 GM138552NIGMS NIH HHS P30 GM127200NIGMS NIH HHS P30GM127200NIGMS NIH HHS R01 GM138552
6 · The paper itself

Abstract

Biofilm infection has a high prevalence in chronic wounds and can delay wound healing. Current treatment using debridement and antibiotic administration imposes a significant burden on patients and healthcare systems. To address their limitations, a highly efficacious electrical antibiofilm treatment system is described in this paper. This system uses high-intensity current (75 mA cm

Indexed as

Bacterial InfectionsMethicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsWound InfectionAnimalsAnti-Bacterial AgentsBiofilmsDisease Models, AnimalMiceAnti-Bacterial Agentsbiofilmchronic wound infectionelectrical debridementhydrogel ionic circuitiontophoretic antibiotic delivery

Identifiers

PMID36385439
PMCPMC9918715
OpenAlexW4309246416

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.