Evidence map›Paper›PMID 36385314›Full record

Trial reportEuropean journal of nutrition2023

The effect of caffeine on exercise performance is not influenced by ADORA2A genotypes, alone or pooled with CYP1A2 genotypes, in adolescent athletes.

Maryssa P Pinto Dos Santos, Higor Spineli, Bruna P Dos Santos, Adriano E Lima-Silva, Daniel L G Gitaí, David J Bishop, Gustavo Gomes de Araujo

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Maryssa P Pinto Dos SantosPostgraduate Program in Nutrition-PPGNUT, Federal University of Alagoas, Maceió, AL, Brazil.ORCID http://orcid.org/0000-0003-2840-865X
Higor SpineliPostgraduate Program in Nutrition-PPGNUT, Federal University of Alagoas, Maceió, AL, Brazil.ORCID http://orcid.org/0000-0001-6992-8817
Bruna P Dos SantosPostgraduate Program in Health Sciences-PPGCS, Federal University of Alagoas, Maceió, AL, Brazil.ORCID http://orcid.org/0000-0002-3694-9977
Adriano E Lima-SilvaHuman Performance Research Group, Federal University of Technology Parana, Curitiba, PR, Brazil.ORCID http://orcid.org/0000-0002-0613-5104
Daniel L G GitaíPostgraduate Program in Health Sciences-PPGCS, Federal University of Alagoas, Maceió, AL, Brazil.ORCID http://orcid.org/0000-0001-7056-2373
David J BishopInstitute of Sport, Exercise and Active Living. School of Sport and Exercise Science, Victoria University, Melbourne, VU, Australia.ORCID http://orcid.org/0000-0002-6956-9188
Gustavo Gomes de AraujoPostgraduate Program in Nutrition-PPGNUT, Federal University of Alagoas, Maceió, AL, Brazil. gusta_ef@yahoo.com.br.ORCID http://orcid.org/0000-0003-4609-069X
Universidade Federal de Alagoas · BRCentro Universitário Cesmac · BRUniversidade Tecnológica Federal do Paraná · BRVictoria University · AU

Funding

Coordination for the Improvement of Higher Education Personnel 001Fundação de Amparo à Pesquisa do Estado de Alagoas 60030 1121/2015
6 · The paper itself

Abstract

purposeThis study investigated the influence of the different genotypes of ADORA2A (1976 C > T, rs 5751876), alone or pooled with CYP1A2 (163 C > A rs 762551) genotypes, on the ergogenic effects of caffeine (CAF) on various aspects of physical performance in male adolescent athletes.

methodsNinety male adolescent athletes (age = 15.5 ± 2 years) were classified according to their genotypes for 1976 C > T ADORA2A (TT homozygous or C

resultsCAF enhanced handgrip strength (CAF: 35.0 ± 9.2 kg force; PLA: 33.5 ± 8.9 kg force; p = 0.050), CMJ height (CAF: 49.6 ± 12.3 cm; PLA: 48.3 ± 13.6 cm; p = 0.013), SJ height (CAF: 54.7 ± 13.3 cm; PLA: 53.1 ± 14.8 cm; p = 0.013), number of sit-ups (CAF: 37 ± 8; PLA: 35 ± 8; p = 0.001), and distance covered on the Yoyo IR1 test (CAF: 991.6 ± 371.0 m; PLA: 896.0 ± 311.0 m; p = 0.001), This CAF-induced improvement on exercise performance was, however, independent of genotypes groups (all p > 0.05). CAF had no effect on agility (CAF: 15.8 ± 1.2 s; PLA: 15.9 ± 1.3 s; p = 0.070) and push-up (CAF: 26.6 ± 12.0; PLA: 25.0 ± 11.0; p = 0.280) tests.

conclusionThe acute caffeine intake of 6.0 mg.kg

Indexed as

Athletic PerformanceCaffeineAdolescentAthletesCross-Over StudiesCytochrome P-450 CYP1A2Double-Blind MethodGenotypeHand StrengthHumansMalePolyestersCaffeineCYP1A2 protein, humanCytochrome P-450 CYP1A2PolyestersADORA2A genotypeCYP genotypeErgogenic effectsExerciseGenetic polymorphismTeenagersXanthine

Identifiers

PMID36385314
OpenAlexW4309245422

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.