ArticleScientific reports2022
Comprehensive dynamic and kinematic analysis of the rodent hindlimb during over ground walking.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Automatic registration of generic bone models for X-ray-based biomechanics: Application to 3D rat hindlimb kinematics and sex-specific gait patterns.Computers in biology and medicine · 2026Article
- Effects of two exercise modalities and subsequent detraining on trabecular bone microarchitecture in growing male rats.Physiological reports · 2026Article
- Assessing Time-Frequency Analysis Methods for Non-Stationary EMG Bursts: Application to an Animal Model of Parkinson's Disease.Sensors (Basel, Switzerland) · 2026Article
- Ex vivo robotic measurement of the acute biomechanical impact of anterior cruciate ligament rupture in rats.Journal of biomechanics · 2025Article
- Development and validation of a kinematic hindlimb cycling model for rats.Scientific reports · 2025Article
- Morphometric analysis of rat and mouse musculoskeletal tissues using high field MRI.Scientific reports · 2025Article
- Gait assessment in a female rat Sprague Dawley model of disc-associated low back pain.Connective tissue research · 2024Article
- Prediction of isometric forces from combined epidural spinal cord and neuromuscular electrical stimulation in the rat lower limb.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rat hindlimb is a frequently utilized pre-clinical model system to evaluate injuries and pathologies impacting the hindlimbs. These studies have demonstrated the translational potential of this model but have typically focused on the force generating capacity of target muscles as the primary evaluative outcome. Historically, human studies investigating extremity injuries and pathologies have utilized biomechanical analysis to better understand the impact of injury and extent of recovery. In this study, we expand that full biomechanical workup to a rat model in order to characterize the spatiotemporal parameters, ground reaction forces, 3-D joint kinematics, 3-D joint kinetics, and energetics of gait in healthy rats. We report data on each of these metrics that meets or exceeds the standards set by the current literature and are the first to report on all these metrics in a single set of animals. The methodology and findings presented in this study have significant implications for the development and clinical application of the improved regenerative therapeutics and rehabilitative therapies required for durable and complete functional recovery from extremity traumas, as well as other musculoskeletal pathologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.