Evidence map›Paper›PMID 36384979›Full record

ReviewExperimental hematology & oncology2022

The role of neutrophil extracellular traps in cancer progression, metastasis and therapy.

Yue Chen, Haoyue Hu, Songtao Tan, Qionglan Dong, Xue Fan, Yi Wang, Huan Zhang, Jun He

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental hematology & oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06967662 (Pilot Study of the Effectiveness of Selective Plasma Adsorption of Extracellular DNA as a Method for Preventing Intraoperative Metastasis in Pancreatic Cancer), which is not on this map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06967662 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Pilot Study of the Effectiveness of Selective Plasma Adsorption of Extracellular DNA as a Method for Preventing Intraoperative Metastasis in Pancreatic Cancer

TypeinterventionalSponsorIlyinskaya Hospital, JSCRan2025 to 2027Enrolled28ConditionsPancreatic Ductal Adenocarcinoma (PDAC)ArmsSelective plasma adsorption of extracellular DNA
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Neutrophil extracellular traps (NETosis) in gynecologic cancers: from pathogenesis to therapeutic opportunities: a narrative review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
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  7. Article
  8. Review
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  11. Review
  12. Review
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  18. Progress in the mechanistic understanding of NETs formation in cancer.Medical oncology (Northwood, London, England) · 2025
    Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Yue Chen *Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
Haoyue Hu *Department of Medical Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Medicine School of University of Electronic Science and Technology, Chengdu, 610041, China.
Songtao Tan *West China School of Medicine, Sichuan University, Chengdu, 610041, China.
Qionglan Dong *Southeast Medical University, Luzhou, 646099, China.
Xue FanSouthern Medical University, Guangzhou, 510515, China.
Yi WangDepartment of Medical Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Medicine School of University of Electronic Science and Technology, Chengdu, 610041, China.
Huan ZhangDepartment of Medical Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Medicine School of University of Electronic Science and Technology, Chengdu, 610041, China.
Jun HeDepartment of Oncology, The Third Hospital of Mianyang (Sichuan Mental Health Center), Mianyang, 621015, China. he-001jun@163.com.
Sichuan Cancer Hospital · CNBeijing Shijitan Hospital · CNMianyang Third People's Hospital · CNSichuan University · CNSoutheast University · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutrophil extracellular traps (NETs) released by activated neutrophils typically consist of DNA-histone complexes and granule proteins. NETs were originally identified as a host defense system against foreign pathogens and are strongly associated with autoimmune diseases. However, a novel and predominant role of NETs in cancer is emerging. Increasing evidence has confirmed that many stimuli can facilitate NET formation in an NADPH oxidase (NOX)-dependent/NOX-independent manner. In cancer, NETs have been linked to cancer progression, metastasis, and cancer-associated thrombosis. In this review, we aimed to summarize the current available knowledge regarding NET formation and focused on the role of NETs in cancer biological behaviors. The potential target for cancer therapy will be further discussed.

Indexed as

CancerMetastasisNeutrophilNeutrophil extracellular trapsTargeted therapy

Identifiers

PMID36384979
PMCPMC9667637
OpenAlexW4309323103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.