SynthesisEpidemiology and psychiatric sciences2022
Colorectal cancer treatment in people with severe mental illness: a systematic review and meta-analysis.
Synthesis in Epidemiology and psychiatric sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Colorectal cancer mortality in persons with severe mental illness: a scoping review with meta-analyses of observational studies.Acta oncologica (Stockholm, Sweden) · 2025Pooled it
- Impact of pre-existing schizophrenia spectrum disorder on the receipt of invasive and systemic therapy for gastric cancer: a multicenter nationwide cohort study in Japan.Japanese journal of clinical oncology · 2026Article
- The experiences of people diagnosed with severe mental illness and colorectal cancer: A qualitative study.Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists · 2026Article
- Integrative omics identify NID2 as a therapeutic target linking depression and colorectal cancer in humans.iScience · 2026Article
- Outcomes after pulmonary resection for malignancy in patients with severe and persistent mental illness.Journal of cardiothoracic surgery · 2026Article
- Impact of Schizophrenia Spectrum Disorders on the Receipt of Invasive and Systemic Therapy for Colorectal Cancer: A Nationwide Multicenter Retrospective Cohort Study in Japan.Acta psychiatrica Scandinavica · 2026Article
- Mental illness and non-metastatic colorectal cancer treatment and survival, a nationwide study of almost 70,000 patients.Acta oncologica (Stockholm, Sweden) · 2025Article
- Bridging the Gap: Interventions to Increase Cancer Screening Adherence in Individuals with Mental Disorders-A Systematic Review.Behavioral sciences (Basel, Switzerland) · 2025Review
- Impact of lifestyle and mental health on colorectal adenomas in China: a prospective cross-sectional survey.Frontiers in medicine · 2025Article
- The Challenging Problems of Cancer and Serious Mental Illness.Current psychiatry reports · 2025Review
- Rates of colorectal cancer diagnosis and mortality in people with severe mental illness: results from Australia's National Bowel Cancer Screening Programme.Epidemiology and psychiatric sciences · 2024Article
- Participation in the National Bowel Cancer Screening Program by people with severe mental illness, Australia, 2006-2019: a national data linkage study.The Medical journal of Australia · 2024Article
- Application of fecal immunochemical test in colorectal cancer screening: A community-based, cross-sectional study in average-risk individuals in Hainan.World journal of gastrointestinal oncology · 2024Article
- The double burden of severe mental illness and cancer: a population-based study on colorectal cancer care pathways from screening to end-of-life care.Epidemiology and psychiatric sciences · 2024Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
aimsPeople with severe mental illness (SMI) have a greater risk of dying from colorectal cancer (CRC), even though the incidence is lower or similar to that of the general population This pattern is unlikely to be solely explained by lifestyle factors, while the role of differences in cancer healthcare access or treatment is uncertain.
methodsWe undertook a systematic review and meta-analysis on access to guideline-appropriate care following CRC diagnosis in people with SMI including the receipt of surgery, chemo- or radiotherapy. We searched for full-text articles indexed by PubMed, EMBASE, PsychInfo and CINAHL that compared CRC treatment in those with and without pre-existing SMI (schizophrenia, schizoaffective, bipolar and major affective disorders). Designs included cohort or population-based case-control designs.
resultsThere were ten studies (sample size = 3501-591 561). People with SMI had a reduced likelihood of surgery (RR = 0.90, 95% CI 0.92-0.97;
conclusionsPeople with SMI, including both psychotic and affective disorders, receive less CRC care than the general population. This might contribute to higher case-fatality rates for an illness where the incidence is no higher than that of the general population. The reasons for this require further investigation, as does the extent to which differences in treatment access or quality contribute to excess CRC mortality in people with SMI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.