ArticleHeart (British Cardiac Society)2023
Lower birth weight is linked to poorer cardiovascular health in middle-aged population-based adults.
Article in Heart (British Cardiac Society), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Infant fat mass and later child and adolescent health outcomes: a systematic review.Archives of disease in childhood · 2024Pooled it
- Understanding physiological adaptations of pregnancy to the chronic hypoxia of high altitude to inform obstetrical and neonatal care.Physiological reviews · 2026Review
- Placental DNA methylation captures shared and trait-specific genetic susceptibility across complex health conditions.medRxiv : the preprint server for health sciences · 2026Article
- Environmental Exposures and Atherosclerotic Risk Factors in Vulnerable Youth: The Example of American Indian/Alaska Native Populations.Current atherosclerosis reports · 2026Review
- Associations between maternal fish intakes, maternal and cord PUFA and longitudinal measures of child weight at birth, 20 months and at 7 and 13 years of age.The British journal of nutrition · 2026Article
- Offspring BMI and lipid profiles following assisted reproductive technology: a comparative study of underweight and normal-weight mothers.Lipids in health and disease · 2026Article
- Maternal mineral nutrition during early pregnancy and neonatal growth: findings from a China birth cohort study.Frontiers in nutrition · 2026Article
- Small left ventricular size as a predictor for incident type 2 diabetes: insights from the UK biobank cardiovascular magnetic resonance substudy.Diabetology & metabolic syndrome · 2025Article
- From Womb to Tomb: A Life-Course Perspective on the Origins of Non-communicable Diseases.Cureus · 2025Review
- Metabolic dysfunction over a life course key to healthy ageing inequality.Aging clinical and experimental research · 2025Review
- Fetal birthweight and maternal urinary incontinence in Chinese primiparas: a population-based study.BMC public health · 2025Article
- Early life factors and variation in adult kidney function in the Swedish LifeGene cohort.Scientific reports · 2025Article
- Cardiac remodeling and exercise tolerance in small for gestational age: a follow-up cohort study from preadolescence into adolescence.Frontiers in cardiovascular medicine · 2025Article
- Improving life's essential 8 mitigates myocardial infarction risk attributed to abnormal birth weight in later life.Preventive medicine reports · 2024Article
- Epigenetic scores derived in saliva are associated with gestational age at birth.Clinical epigenetics · 2024Article
- FGR-associated placental insufficiency and capillary angiogenesis involves disruptions in human placental miRNAs and mRNAs.Heliyon · 2024Article
- Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association.European heart journal · 2024Article
- Exercise Capacity in Very Low Birth Weight Adults: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo examine associations of birth weight with clinical and imaging indicators of cardiovascular health and evaluate mechanistic pathways in the UK Biobank.
methodsCompeting risk regression was used to estimate associations of birth weight with incident myocardial infarction (MI) and mortality (all-cause, cardiovascular disease, ischaemic heart disease, MI), over 7-12 years of longitudinal follow-up, adjusting for age, sex, deprivation, maternal smoking/hypertension and maternal/paternal diabetes. Mediation analysis was used to evaluate the role of childhood growth, adulthood obesity, cardiometabolic diseases and blood biomarkers in mediating the birth weight-MI relationship. Linear regression was used to estimate associations of birth weight with left ventricular (LV) mass-to-volume ratio, LV stroke volume, global longitudinal strain, LV global function index and left atrial ejection fraction.
results258 787 participants from white ethnicities (61% women, median age 56 (49, 62) years) were studied. Birth weight had a non-linear relationship with incident MI, with a significant inverse association below an optimal threshold of 3.2 kg (subdistribution HR: 1.15 (1.08 to 1.22), p=6.0×10
conclusionsLower birth weight was associated with greater risk of incident MI and unhealthy LV phenotypes; effects were partially mediated through cardiometabolic disease and systemic inflammation. These findings support consideration of birth weight in risk prediction and highlight actionable areas for disease prevention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.